1HWL
COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH ROSUVASTATIN (FORMALLY KNOWN AS ZD4522)
Summary for 1HWL
Entry DOI | 10.2210/pdb1hwl/pdb |
Related | 1dq8 1dq9 1dqa 1HW8 1HW9 1HWI 1HWJ 1HWK |
Descriptor | HMG-COA REDUCTASE, ADENOSINE-5'-DIPHOSPHATE, 7-[4-(4-FLUORO-PHENYL)-6-ISOPROPYL-2-(METHANESULFONYL-METHYL-AMINO)-PYRIMIDIN-5-YL] -3,5-DIHYDROXY-HEPTANOIC ACID, ... (4 entities in total) |
Functional Keywords | protein-inhibitor complex, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein: P04035 |
Total number of polymer chains | 4 |
Total formula weight | 203301.91 |
Authors | Istvan, E.S.,Deisenhofer, J. (deposition date: 2001-01-09, release date: 2001-05-11, Last modification date: 2023-08-09) |
Primary citation | Istvan, E.S.,Deisenhofer, J. Structural mechanism for statin inhibition of HMG-CoA reductase. Science, 292:1160-1164, 2001 Cited by PubMed: 11349148DOI: 10.1126/science.1059344 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report