1HW9

COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH SIMVASTATIN

Summary for 1HW9

Entry DOI	10.2210/pdb1hw9/pdb
Related	1HW8 1HWI 1HWJ 1HWK 1HWL 1dq8 1dq9 1dqa
Descriptor	HMG-COA REDUCTASE, ADENOSINE-5'-DIPHOSPHATE, Simvastatin acid, ... (4 entities in total)
Functional Keywords	protein-inhibitor complex, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein: P04035
Total number of polymer chains	4
Total formula weight	203968.43
Authors	Istvan, E.S.,Deisenhofer, J. (deposition date: 2001-01-09, release date: 2001-05-11, Last modification date: 2023-08-09)
Primary citation	Istvan, E.S.,Deisenhofer, J. Structural mechanism for statin inhibition of HMG-CoA reductase. Science, 292:1160-1164, 2001 Cited by PubMed: 11349148 DOI: 10.1126/science.1059344 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation