1HW9
COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH SIMVASTATIN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | HMG-COA REDUCTASE | polymer | 467 | 50021.5 | 4 | UniProt (P04035) Pfam (PF00368) In PDB | Homo sapiens (human) | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE, HYDROXYMETHYLGLUTARYL-COA REDUCTASE |
| 2 | A, B, C, D | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 5 | Chemie (ADP) | |||
| 3 | A, B, C | Simvastatin acid | non-polymer | 436.6 | 4 | Chemie (SIM) | |||
| 4 | water | water | 18.0 | 176 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 426 - 888 (UniProt: P04035)
| PDB | External Database | Details |
|---|---|---|
| Gly 422 | - | insertion |
| Ala 423 | - | insertion |
| Met 424 | - | insertion |
| Ala 425 | - | insertion |
| Ile 485 | Met 485 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 200086.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 3882.3 | |
| All* | Total formula weight | 203968.4 |
