1HW8
COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH COMPACTIN (ALSO KNOWN AS MEVASTATIN)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | HMG-COA REDUCTASE | polymer | 467 | 50021.5 | 4 | UniProt (P04035) Pfam (PF00368) | Homo sapiens (human) | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE, HYDROXYMETHYLGLUTARYL-COA REDUCTASE |
| 2 | E, F, H, I (A, B, C, D) | (3R,5R)-3,5-dihydroxy-7-[(1S,2S,8S,8aR)-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]h eptanoic acid | non-polymer | 408.5 | 4 | Chemie (114) PubChem (92853255) PubChem (133554309) PubChem (446154) PubChem (4468721) PubChem (124584846) PubChem (9844355) PubChem (12940238) PubChem (23259248) PubChem (143871027) PubChem (146160906) PubChem (23899997) PubChem (44303221) PubChem (51537033) PubChem (60132055) PubChem (92853254) PubChem (38349409) | |||
| 3 | G, J (B, D) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 4 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 287 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 426 - 888 (UniProt: P04035)
| PDB | External Database | Details |
|---|---|---|
| Gly 422 | - | insertion |
| Ala 423 | - | insertion |
| Met 424 | - | insertion |
| Ala 425 | - | insertion |
| Ile 485 | Met 485 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 200086.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2488.5 | |
| All* | Total formula weight | 202574.6 |
