1FCM

CRYSTAL STRUCTURE OF THE E.COLI AMPC BETA-LACTAMASE MUTANT Q120L/Y150E COVALENTLY ACYLATED WITH THE INHIBITORY BETA-LACTAM, CLOXACILLIN

Summary for 1FCM

• Entry DOI: 10.2210/pdb1fcm/pdb
• Related: 1FCN 1FCO
• Descriptor: BETA-LACTAMASE, CLOXACILLIN (OPEN FORM) (3 entities in total)
• Functional Keywords: beta-lactamase beta-lactam complex, enzyme inhibitor complex, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Escherichia coli
• Cellular location: Periplasm: P00811
• Total number of polymer chains: 2
• Total formula weight: 79953.58

Authors

Patera, A.,Blaszczak, L.C.,Shoichet, B.K. (deposition date: 2000-07-18, release date: 2000-12-04, Last modification date: 2024-10-30)

• Primary citation: Patera, A.,Blaszczak, L.C.,Shoichet, B.K.; Crystal Structures of Substrate and Inhibitor Complexes with AmpC -Lactamase: Possible Implications for Substrate-Assisted Catalysis; J.Am.Chem.Soc., 122:10504-10512, 2000; DOI: 10.1021/ja001676x

Experimental method

X-RAY DIFFRACTION (2.46 Å)