1FCM

CRYSTAL STRUCTURE OF THE E.COLI AMPC BETA-LACTAMASE MUTANT Q120L/Y150E COVALENTLY ACYLATED WITH THE INHIBITORY BETA-LACTAM, CLOXACILLIN

Summary for 1FCM

Related1FCN 1FCO
DescriptorBETA-LACTAMASE, CLOXACILLIN (OPEN FORM) (3 entities in total)
Functional Keywordsbeta-lactamase beta-lactam complex, enzyme inhibitor complex, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological sourceEscherichia coli
Cellular locationPeriplasm P00811
Total number of polymer chains2
Total molecular weight79953.58
Authors
Patera, A.,Blaszczak, L.C.,Shoichet, B.K. (deposition date: 2000-07-18, release date: 2000-12-04, Last modification date: 2018-01-31)
Primary citation
Patera, A.,Blaszczak, L.C.,Shoichet, B.K.
Crystal Structures of Substrate and Inhibitor Complexes with AmpC -Lactamase: Possible Implications for Substrate-Assisted Catalysis
J.Am.Chem.Soc., 122:10504-10512, 2000
DOI: 10.1021/ja001676x
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.46 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers220.4%8.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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168889
PDB entries from 2020-09-16