1FCN

Crystal Structure of the E. Coli AMPC Beta-Lactamase Mutant Q120L/Y150E Covalently Acylated with the Substrate Beta-Lactam LORACARBEF

Summary for 1FCN

• Entry DOI: 10.2210/pdb1fcn/pdb
• Related: 1FCM 1FCO
• Descriptor: BETA-LACTAMASE, LORACABEF (Open form) (3 entities in total)
• Functional Keywords: beta-lactamase beta-lactam complex, enzyme inhibitor complex, hydrolase
• Biological source: Escherichia coli
• Cellular location: Periplasm: P00811
• Total number of polymer chains: 2
• Total formula weight: 79781.35

Authors

Patera, A.,Blaszczak, L.C.,Shoichet, B.K. (deposition date: 2000-07-18, release date: 2000-12-04, Last modification date: 2021-11-03)

• Primary citation: Patera, A.,Blaszczak, L.C.,Shoichet, B.K.; Crystal Structures of Substrate and Inhibitor Complexes with AmpC -Lactamase: Possible Implications for Substrate-Assisted Catalysis; J.Am.Chem.Soc., 122:10504-10512, 2000; DOI: 10.1021/ja001676x

Experimental method

X-RAY DIFFRACTION (2.35 Å)