1FCO

CRYSTAL STRUCTURE OF THE E. COLI AMPC BETA-LACTAMASE COVALENTLY ACYLATED WITH THE INHIBITORY BETA-LACTAM, MOXALACTAM

Summary for 1FCO

• Entry DOI: 10.2210/pdb1fco/pdb
• Related: 1FCM 1FCN
• Descriptor: BETA-LACTAMASE, (2R)-2-[(1R)-1-{[(2S)-2-carboxy-2-(4-hydroxyphenyl)acetyl]amino}-1-methoxy-2-oxoethyl]-5-methylidene-5,6-dihydro-2H-1,3-oxazine-4-carboxylic acid (3 entities in total)
• Functional Keywords: beta-lactamase beta-lactam complex, enzyme inhibitor complex, hydrolase
• Biological source: Escherichia coli
• Cellular location: Periplasm: P00811
• Total number of polymer chains: 2
• Total formula weight: 79988.53

Authors

Patera, A.,Blaszczak, L.C.,Shoichet, B.K. (deposition date: 2000-07-19, release date: 2000-12-04, Last modification date: 2017-10-04)

• Primary citation: Patera, A.,Blaszczak, L.C.,Shoichet, B.K.; Crystal Structures of Substrate and Inhibitor Complexes with AmpC -Lactamase: Possible Implications for Substrate-Assisted Catalysis; J.Am.Chem.Soc., 122:10504-10512, 2000; DOI: 10.1021/ja001676x

Experimental method

X-RAY DIFFRACTION (2.2 Å)