1FCO
CRYSTAL STRUCTURE OF THE E. COLI AMPC BETA-LACTAMASE COVALENTLY ACYLATED WITH THE INHIBITORY BETA-LACTAM, MOXALACTAM
Summary for 1FCO
Entry DOI | 10.2210/pdb1fco/pdb |
Related | 1FCM 1FCN |
Descriptor | BETA-LACTAMASE, (2R)-2-[(1R)-1-{[(2S)-2-carboxy-2-(4-hydroxyphenyl)acetyl]amino}-1-methoxy-2-oxoethyl]-5-methylidene-5,6-dihydro-2H-1,3-oxazine-4-carboxylic acid (3 entities in total) |
Functional Keywords | beta-lactamase beta-lactam complex, enzyme inhibitor complex, hydrolase |
Biological source | Escherichia coli |
Cellular location | Periplasm: P00811 |
Total number of polymer chains | 2 |
Total formula weight | 79988.53 |
Authors | Patera, A.,Blaszczak, L.C.,Shoichet, B.K. (deposition date: 2000-07-19, release date: 2000-12-04, Last modification date: 2017-10-04) |
Primary citation | Patera, A.,Blaszczak, L.C.,Shoichet, B.K. Crystal Structures of Substrate and Inhibitor Complexes with AmpC -Lactamase: Possible Implications for Substrate-Assisted Catalysis J.Am.Chem.Soc., 122:10504-10512, 2000 Cited by DOI: 10.1021/ja001676xPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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