1EMH

CRYSTAL STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO UNCLEAVED SUBSTRATE-CONTAINING DNA

Summary for 1EMH

• Entry DOI: 10.2210/pdb1emh/pdb
• Related: 1AKZ 1SSP 2SSP 4SKN
• Descriptor: DNA (5'-D(*TP*GP*TP*(P2U)P*AP*TP*CP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*AP*CP*A)-3'), URACIL-DNA GLYCOSYLASE, ... (4 entities in total)
• Functional Keywords: alpha/beta fold, uracil-dna glycosylase, protein/dna, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Mitochondrion. Isoform 2: Nucleus: P13051
• Total number of polymer chains: 3
• Total formula weight: 31311.98

Authors

Parikh, S.S.,Slupphaug, G.,Krokan, H.E.,Blackburn, G.M.,Tainer, J.A. (deposition date: 2000-03-16, release date: 2000-05-16, Last modification date: 2024-02-07)

• Primary citation: Parikh, S.S.,Walcher, G.,Jones, G.D.,Slupphaug, G.,Krokan, H.E.,Blackburn, G.M.,Tainer, J.A.; Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.; Proc.Natl.Acad.Sci.USA, 97:5083-5088, 2000; PubMed: 10805771; DOI: 10.1073/pnas.97.10.5083

Experimental method

X-RAY DIFFRACTION (1.8 Å)