1EMH

CRYSTAL STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO UNCLEAVED SUBSTRATE-CONTAINING DNA

Summary for 1EMH

Related1SSP 2SSP 4SKN 1AKZ
DescriptorDNA (5'-D(*TP*GP*TP*(P2U)P*AP*TP*CP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*AP*CP*A)-3'), URACIL-DNA GLYCOSYLASE, ... (4 entities in total)
Functional Keywordsalpha/beta fold, uracil-dna glycosylase, protein/dna, hydrolase-dna complex, hydrolase/dna
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Mitochondrion. Isoform 2: Nucleus P13051
Total number of polymer chains3
Total molecular weight31311.98
Authors
Parikh, S.S.,Slupphaug, G.,Krokan, H.E.,Blackburn, G.M.,Tainer, J.A. (deposition date: 2000-03-16, release date: 2000-05-16, Last modification date: 2017-10-04)
Primary citation
Parikh, S.S.,Walcher, G.,Jones, G.D.,Slupphaug, G.,Krokan, H.E.,Blackburn, G.M.,Tainer, J.A.
Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Proc.Natl.Acad.Sci.USA, 97:5083-5088, 2000
PubMed: 10805771 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.97.10.5083
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers303.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution