1E9C

Mutant human thymidylate kinase complexed with TMP and APPNP

Summary for 1E9C

Entry DOI	10.2210/pdb1e9c/pdb
Related	1E2D 1E2E 1E2F 1E2G 1E2Q 1E98 1E99 1E9A 1E9B 1E9D 1E9E 1E9F
Descriptor	THYMIDYLATE KINASE, THYMIDINE-5'-PHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywords	phosphotransferase, thymidylate kinase, p-loop, transferase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	25444.88
Authors	Ostermann, N.,Lavie, A.,Padiyar, S.,Brundiers, R.,Veit, T.,Reintein, J.,Goody, R.S.,Konrad, M.,Schlichting, I. (deposition date: 2000-10-10, release date: 2001-10-11, Last modification date: 2019-03-06)
Primary citation	Ostermann, N.,Lavie, A.,Padiyar, S.,Brundiers, R.,Veit, T.,Reintein, J.,Goody, R.S.,Konrad, M.,Schlichting, I. Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304:43-, 2000 Cited by PubMed: 11071809 DOI: 10.1006/JMBI.2000.4175 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation