1E9C
Mutant human thymidylate kinase complexed with TMP and APPNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | THYMIDYLATE KINASE | polymer | 215 | 24140.7 | 1 | UniProt (P23919) Pfam (PF02223) | HOMO SAPIENS (HUMAN) | DTMP KINASE |
| 2 | B (A) | THYMIDINE-5'-PHOSPHATE | non-polymer | 322.2 | 1 | Chemie (TMP) PubChem (18531120) PubChem (20711568) PubChem (1139) PubChem (23657880) PubChem (24802545) PubChem (44361457) PubChem (25113134) PubChem (51397487) PubChem (444919) PubChem (9700) PubChem (5274091) PubChem (5748250) PubChem (10147784) PubChem (129069890) PubChem (133126478) PubChem (164603144) | |||
| 3 | C (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 5 | E, F (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | G (A) | water | water | 18.0 | 262 | Chemie (HOH) |
Sequence modifications
A: -3 - -1 (PDB: 1E9C)
A: 1 - 212 (UniProt: P23919)
A: 1 - 212 (UniProt: P23919)
| PDB | External Database | Details |
|---|---|---|
| Ala 200 | Arg 200 | engineered mutation |
| Ser 183 | Arg 183 | conflict |
| Asp 190 | Glu 190 | conflict |
| Ile 184 | Leu 184 | conflict |
| Ile 191 | Leu 191 | conflict |
| Tyr 105 | Phe 105 | conflict |
| Lys 208 | Gly 208 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24140.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1304.2 | |
| All* | Total formula weight | 25444.9 |
