1E9C
Mutant human thymidylate kinase complexed with TMP and APPNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | THYMIDYLATE KINASE | polymer | 215 | 24140.7 | 1 | UniProt (P23919) Pfam (PF02223) | HOMO SAPIENS (HUMAN) | DTMP KINASE |
| 2 | B (A) | THYMIDINE-5'-PHOSPHATE | non-polymer | 322.2 | 1 | Chemie (TMP) | |||
| 3 | C (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 5 | E, F (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | G (A) | water | water | 18.0 | 262 | Chemie (HOH) |
Sequence modifications
A: -3 - -1 (PDB: 1E9C)
A: 1 - 212 (UniProt: P23919)
A: 1 - 212 (UniProt: P23919)
| PDB | External Database | Details |
|---|---|---|
| Ala 200 | Arg 200 | engineered mutation |
| Ser 183 | Arg 183 | conflict |
| Asp 190 | Glu 190 | conflict |
| Ile 184 | Leu 184 | conflict |
| Ile 191 | Leu 191 | conflict |
| Tyr 105 | Phe 105 | conflict |
| Lys 208 | Gly 208 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24140.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1304.2 | |
| All* | Total formula weight | 25444.9 |
