1E2L

Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine

1E2L の概要

• エントリーDOI: 10.2210/pdb1e2l/pdb
• 関連するPDBエントリー: 1E2H 1E2I 1E2J 1E2K 1E2M 1E2N 1E2P 1KI2 1KI4 1KI5 1KI6 1KI7 1KI8 1KIM 1VTK 2VTK 3VTK
• 分子名称: THYMIDINE KINASE, SULFATE ION, 1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE, ... (4 entities in total)
• 機能のキーワード: thymidine kinase, antiviral drug, enzyme-prodrug gene therapy, sugar ring pucker
• 由来する生物種: HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN 17)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72222.83

構造登録者

Vogt, J.,Scapozza, L.,Schulz, G.E. (登録日: 2000-05-23, 公開日: 2000-08-18, 最終更新日: 2023-12-06)

• 主引用文献: Prota, A.,Vogt, J.,Pilger, B.,Perozzo, R.,Wurth, C.,Marquez, V.,Russ, P.,Schulz, G.E.,Folkers, G.,Scapozza, L.; Kinetics and Crystal Structure of the Wild-Type and the Engineered Y101F Mutant of Herpes Simplex Virus Type 1 Thymidine Kinase Interacting with (North)-Methanocarba-Thymidine; Biochemistry, 39:9597-, 2000; PubMed: 10924157; DOI: 10.1021/BI000668Q

実験手法

X-RAY DIFFRACTION (2.4 Å)