1E1X

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU6027

Summary for 1E1X

Entry DOI	10.2210/pdb1e1x/pdb
Related	1AQ1 1B38 1B39 1BUH 1CKP 1E1V 1FIN 1HCK 1HCL 1JST 1JSU
Descriptor	CYCLIN-DEPENDENT PROTEIN KINASE 2, 6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE (3 entities in total)
Functional Keywords	protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	34253.81
Authors	Endicott, J.A.,Noble, M.E.M.,Johnson, L.N. (deposition date: 2000-05-11, release date: 2001-05-10, Last modification date: 2023-12-06)
Primary citation	Arris, C.E.,Boyle, F.T.,Calvert, A.H.,Curtin, N.J.,Endicott, J.A.,Garman, E.F.,Gibson, A.E.,Golding, B.T.,Grant, S.,Griffin, R.J.,Jewsbury, P.,Johnson, L.N.,Lawrie, A.M.,Newell, D.R.,Noble, M.E.M.,Sausville, E.A.,Schultz, R.,Yu, W. Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles. J.Med.Chem., 43:2797-, 2000 Cited by PubMed: 10956187 DOI: 10.1021/JM990628O PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation