1DWE

Crystallographic analysis at 3.0-Angstroms resolution of the binding to human thrombin of four active site-directed inhibitors

Summary for 1DWE

• Entry DOI: 10.2210/pdb1dwe/pdb
• Related: 1DWB 1DWC 1DWD
• Related PRD ID: PRD_000020
• Descriptor: ALPHA-THROMBIN light chain, ALPHA-THROMBIN heavy chain, HIRUDIN IIIA, ... (5 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, serine proteinase, hydrolase/hydrolase inhibitor
• Biological source: Hirudo medicinalis (Medicinal leech); More
• Cellular location: Secreted, extracellular space: P00734 P00734; Secreted: P28507
• Total number of polymer chains: 3
• Total formula weight: 35742.20

Authors

Banner, D.W.,Hadvary, P. (deposition date: 1992-08-19, release date: 1994-01-31, Last modification date: 2013-02-27)

• Primary citation: Banner, D.W.,Hadvary, P.; Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.; J.Biol.Chem., 266:20085-20093, 1991; PubMed: 1939071

Experimental method

X-RAY DIFFRACTION (3 Å)