1DWE
Crystallographic analysis at 3.0-Angstroms resolution of the binding to human thrombin of four active site-directed inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | ALPHA-THROMBIN light chain | polymer | 36 | 4096.5 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | |
| 2 | B (H) | ALPHA-THROMBIN heavy chain | polymer | 259 | 29780.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | |
| 3 | C (I) | HIRUDIN IIIA | polymer | 11 | 1411.5 | 1 | UniProt (P28507) UniProt (by SIFTS) (P28508) | Hirudo medicinalis (Medicinal leech) | Hirudin IIIA |
| 4 | D (H) | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide | non-polymer | 454.0 | 1 | BIRD (PRD_000020) Chemie (0G6) | |||
| 5 | E, F, G (L, H, I) | water | water | 18.0 | 55 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 35288.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 454.0 | |
| All* | Total formula weight | 35742.2 |
