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1DWE

Crystallographic analysis at 3.0-Angstroms resolution of the binding to human thrombin of four active site-directed inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
H0004252molecular_functionserine-type endopeptidase activity
H0005509molecular_functioncalcium ion binding
H0006508biological_processproteolysis
H0007596biological_processblood coagulation
L0004252molecular_functionserine-type endopeptidase activity
L0005576cellular_componentextracellular region
L0006508biological_processproteolysis
L0007596biological_processblood coagulation
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE 0G6 H 1
ChainResidue
HHIS57
HSER214
HTRP215
HGLY216
HGLY219
HHOH293
HHOH294
HHOH295
HHOH296
HTYR60
HTRP60
HILE174
HASP189
HALA190
HGLU192
HGLY193
HSER195

site_idAC2
Number of Residues20
DetailsBINDING SITE FOR CHAIN I OF HIRUDIN IIIA
ChainResidue
HLYS36
HGLN38
HARG73
HTHR74
HARG75
HARG75
HTYR76
HILE82
HHIS91
HARG101
HARG233
HLEU234
HLYS236
HTRP237
HGLN239
HLYS240
HHOH251
IHOH16
IHOH17
IHOH19

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
ChainResidueDetails
HLEU53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV
ChainResidueDetails
HASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Sulfotyrosine => ECO:0000250
ChainResidueDetails
ITYR9
HASP102
HSER195

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923
ChainResidueDetails
HASN60

217705

PDB entries from 2024-03-27

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