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1CZ8

VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY

Summary for 1CZ8
Entry DOI10.2210/pdb1cz8/pdb
Related1BJ1 1FLT 1VPF 1VPP
DescriptorVascular endothelial growth factor A, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, HEAVY CHAIN OF NEUTRALIZING ANTIBODY, ... (5 entities in total)
Functional Keywordscomplex (antibody-antigen), cystine knot, fab fragment, immune system
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted : P15692
Total number of polymer chains6
Total formula weight119059.19
Authors
Chen, Y.,Wiesmann, C.,Fuh, G.,Li, B.,Christinger, H.W.,McKay, P.,de Vos, A.M.,Lowman, H.B. (deposition date: 1999-09-01, release date: 2000-03-20, Last modification date: 2017-04-05)
Primary citationChen, Y.,Wiesmann, C.,Fuh, G.,Li, B.,Christinger, H.W.,McKay, P.,de Vos, A.M.,Lowman, H.B.
Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293:865-881, 1999
Cited by
PubMed: 10543973
DOI: 10.1006/jmbi.1999.3192
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

数据于2024-03-27公开中

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