1CZ8

VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY

Summary for 1CZ8

Related1BJ1 1VPF 1FLT 1VPP
DescriptorVascular endothelial growth factor A, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, HEAVY CHAIN OF NEUTRALIZING ANTIBODY, ... (5 entities in total)
Functional Keywordscomplex (antibody-antigen), cystine knot, fab fragment, immune system
Biological sourceHomo sapiens (human)
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Cellular locationSecreted  P15692
Total number of polymer chains6
Total molecular weight119059.19
Authors
Chen, Y.,Wiesmann, C.,Fuh, G.,Li, B.,Christinger, H.W.,McKay, P.,de Vos, A.M.,Lowman, H.B. (deposition date: 1999-09-01, release date: 2000-03-20, Last modification date: 2017-04-05)
Primary citation
Chen, Y.,Wiesmann, C.,Fuh, G.,Li, B.,Christinger, H.W.,McKay, P.,de Vos, A.M.,Lowman, H.B.
Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293:865-881, 1999
PubMed: 10543973 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.1999.3192
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers230.8%13.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution