1C8T

HUMAN STROMELYSIN-1 (E202Q) CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812

Summary for 1C8T

Related1SLM 1HFS 1C3I
DescriptorSTROMELYSIN-1, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywordsprotein-inhibitor complex, mutant protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted, extracellular space, extracellular matrix (Probable) P08254
Total number of polymer chains2
Total molecular weight38802.83
Authors
Steele, D.L.,el-Kabbani, O.,Dunten, P.,Crowther, R.L. (deposition date: 1999-07-29, release date: 2000-07-19, Last modification date: 2011-07-13)
Primary citation
Steele, D.L.,El-Kabbani, O.,Dunten, P.,Windsor, L.J.,Kammlott, R.U.,Crowther, R.L.,Michoud, C.,Engler, J.A.,Birktoft, J.J.
Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1.
Protein Eng., 13:397-405, 2000
PubMed: 10877850 (PDB entries with the same primary citation)
DOI: 10.1093/protein/13.6.397
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
NMR Information
?

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers252.7%16.7%5.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1c8t
no rotation
Molmil generated image of 1c8t
rotated about x axis by 90°
Molmil generated image of 1c8t
rotated about y axis by 90°