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8V9C

HIV-1 Integrase F185H Complexed with Allosteric Inhibitor GSK1264

Replaces:  5HOT
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Integrasepolymer29332744.32UniProt (P12497)
Pfam (PF02022)
Pfam (PF00665)
Pfam (PF00552)
Human immunodeficiency virus 1IN
2C, D
(A, B)
(2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acidnon-polymer453.52Chemie (2SQ)
Sequence modifications
A, B: 2 - 288 (UniProt: P12497)
PDBExternal DatabaseDetails
His 1-expression tag
Ala 15Tyr 1162engineered mutation
His 185Phe 1332engineered mutation
Cys 289-expression tag
Thr 290-expression tag
Leu 291-expression tag
Glu 292-expression tag
Tyr 293-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight65488.6
Non-Polymers*Number of molecules2
Total formula weight907.0
All*Total formula weight66395.7
*Water molecules are not included.

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PDB entries from 2025-06-18

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