8U4P
Structure of AMD3100-bound CXCR4/Gi complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 365 | 41591.3 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38534.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | R | C-X-C chemokine receptor type 4 | polymer | 632 | 71063.6 | 1 | UniProt (P61073) Pfam (PF12109) Pfam (PF00001) UniProt (by SIFTS) (P42212) In PDB | Homo sapiens (human) | |
5 | R | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
6 | R | Plerixafor | non-polymer | 502.8 | 1 | Chemie (VH6) |
Sequence modifications
A: 2 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
R: 2 - 352 (UniProt: P61073)
R: 353 - 614 (PDB: 8U4P)
PDB | External Database | Details |
---|---|---|
Met -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Gly 0 | - | expression tag |
Ser 1 | - | expression tag |
Cys 47 | Ser 47 | conflict |
Thr 202 | Gly 202 | conflict |
Ala 203 | Gly 203 | conflict |
Ala 245 | Glu 245 | conflict |
Ser 326 | Ala 326 | conflict |
PDB | External Database | Details |
---|---|---|
Met -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -17 | - | initiating methionine |
Lys -16 | - | expression tag |
Thr -15 | - | expression tag |
Ile -14 | - | expression tag |
Ile -13 | - | expression tag |
Ala -12 | - | expression tag |
Leu -11 | - | expression tag |
Ser -10 | - | expression tag |
Tyr -9 | - | expression tag |
Ile -8 | - | expression tag |
Phe -7 | - | expression tag |
Cys -6 | - | expression tag |
Leu -5 | - | expression tag |
Val -4 | - | expression tag |
Phe -3 | - | expression tag |
Ala -2 | - | expression tag |
Gly -1 | - | expression tag |
Ala 0 | - | expression tag |
Pro 1 | - | expression tag |
Ser 119 | Asn 119 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 159050.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 889.4 | |
All* | Total formula weight | 159939.6 |