8SIH

Crystal Structure of PRMT4 with Compound YD1-289

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Histone-arginine methyltransferase CARM1	polymer	359	40946.5	1	UniProt (Q86X55) Pfam (PF06325) Pfam (PF22528) In PDB	Homo sapiens (human)	Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4
2	A	5'-{[2-(benzylcarbamamido)ethyl][3-(N'-cyclopentylcarbamimidamido)propyl]amino}-5'-deoxyadenosine	non-polymer		609.7	1	Chemie (I1K)
3	A	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
4		water	water		18.0	80	Chemie (HOH)

Sequence modifications

A: 140 - 480 (UniProt: Q86X55)

PDB	External Database	Details
Met 122	-	initiating methionine
His 123	-	expression tag
His 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
Ser 129	-	expression tag
Ser 130	-	expression tag
Gly 131	-	expression tag
Arg 132	-	expression tag
Glu 133	-	expression tag
Asn 134	-	expression tag
Leu 135	-	expression tag
Tyr 136	-	expression tag
Phe 137	-	expression tag
Gln 138	-	expression tag
Gly 139	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40946.5
Non-Polymers*	Number of molecules	3
	Total formula weight	689.9
All*	Total formula weight	41636.4

*Water molecules are not included.