8IO3

Cryo-EM structure of human HCN3 channel with cilobradine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (C, A, B, D)	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3	polymer	774	86142.9	4	UniProt (Q9P1Z3) Pfam (PF08412) Pfam (PF00520) Pfam (PF00027)	Homo sapiens (human)
2	E, F, G, H (C, A, B, D)	3-[[(3~{S})-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1~{H}-3-benzazepin-4-one	non-polymer		482.6	4	Chemie (VXI)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	344571.7
Non-Polymers*	Number of molecules	4
	Total formula weight	1930.4
All*	Total formula weight	346502.1

*Water molecules are not included.