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8IO3

Cryo-EM structure of human HCN3 channel with cilobradine

Functional Information from GO Data
ChainGOidnamespacecontents
A0003254biological_processregulation of membrane depolarization
A0005216molecular_functionmonoatomic ion channel activity
A0005248molecular_functionvoltage-gated sodium channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005272molecular_functionsodium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006814biological_processsodium ion transport
A0016020cellular_componentmembrane
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030552molecular_functioncAMP binding
A0034702cellular_componentmonoatomic ion channel complex
A0035725biological_processsodium ion transmembrane transport
A0042391biological_processregulation of membrane potential
A0043025cellular_componentneuronal cell body
A0044316cellular_componentcone cell pedicle
A0055085biological_processtransmembrane transport
A0071320biological_processcellular response to cAMP
A0071805biological_processpotassium ion transmembrane transport
A0098855cellular_componentHCN channel complex
A1903351biological_processcellular response to dopamine
B0003254biological_processregulation of membrane depolarization
B0005216molecular_functionmonoatomic ion channel activity
B0005248molecular_functionvoltage-gated sodium channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005272molecular_functionsodium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006814biological_processsodium ion transport
B0016020cellular_componentmembrane
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030552molecular_functioncAMP binding
B0034702cellular_componentmonoatomic ion channel complex
B0035725biological_processsodium ion transmembrane transport
B0042391biological_processregulation of membrane potential
B0043025cellular_componentneuronal cell body
B0044316cellular_componentcone cell pedicle
B0055085biological_processtransmembrane transport
B0071320biological_processcellular response to cAMP
B0071805biological_processpotassium ion transmembrane transport
B0098855cellular_componentHCN channel complex
B1903351biological_processcellular response to dopamine
C0003254biological_processregulation of membrane depolarization
C0005216molecular_functionmonoatomic ion channel activity
C0005248molecular_functionvoltage-gated sodium channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005272molecular_functionsodium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006814biological_processsodium ion transport
C0016020cellular_componentmembrane
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0030552molecular_functioncAMP binding
C0034702cellular_componentmonoatomic ion channel complex
C0035725biological_processsodium ion transmembrane transport
C0042391biological_processregulation of membrane potential
C0043025cellular_componentneuronal cell body
C0044316cellular_componentcone cell pedicle
C0055085biological_processtransmembrane transport
C0071320biological_processcellular response to cAMP
C0071805biological_processpotassium ion transmembrane transport
C0098855cellular_componentHCN channel complex
C1903351biological_processcellular response to dopamine
D0003254biological_processregulation of membrane depolarization
D0005216molecular_functionmonoatomic ion channel activity
D0005248molecular_functionvoltage-gated sodium channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005272molecular_functionsodium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006814biological_processsodium ion transport
D0016020cellular_componentmembrane
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0030552molecular_functioncAMP binding
D0034702cellular_componentmonoatomic ion channel complex
D0035725biological_processsodium ion transmembrane transport
D0042391biological_processregulation of membrane potential
D0043025cellular_componentneuronal cell body
D0044316cellular_componentcone cell pedicle
D0055085biological_processtransmembrane transport
D0071320biological_processcellular response to cAMP
D0071805biological_processpotassium ion transmembrane transport
D0098855cellular_componentHCN channel complex
D1903351biological_processcellular response to dopamine
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2296
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:O60741
ChainResidueDetails
CMET1-ASP97
BARG146-THR171
BARG223-ASN253
BGLN351-MET774
DMET1-ASP97
DARG146-THR171
DARG223-ASN253
DGLN351-MET774
CARG146-THR171
CARG223-ASN253
CGLN351-MET774
AMET1-ASP97
AARG146-THR171
AARG223-ASN253
AGLN351-MET774
BMET1-ASP97

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000250|UniProtKB:O60741
ChainResidueDetails
CLEU98-PHE118
ALEU98-PHE118
BLEU98-PHE118
DLEU98-PHE118

site_idSWS_FT_FI3
Number of Residues176
DetailsTOPO_DOM: Extracellular => ECO:0000250|UniProtKB:O60741
ChainResidueDetails
CLYS119-PRO124
BGLU193-TYR201
BLEU275-GLN297
BVAL320-MET329
DLYS119-PRO124
DGLU193-TYR201
DLEU275-GLN297
DVAL320-MET329
CGLU193-TYR201
CLEU275-GLN297
CVAL320-MET329
ALYS119-PRO124
AGLU193-TYR201
ALEU275-GLN297
AVAL320-MET329
BLYS119-PRO124

site_idSWS_FT_FI4
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000250|UniProtKB:O60741
ChainResidueDetails
CPRO125-PHE145
APRO125-PHE145
BPRO125-PHE145
DPRO125-PHE145

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000250|UniProtKB:O60741
ChainResidueDetails
CTRP172-LEU192
ATRP172-LEU192
BTRP172-LEU192
DTRP172-LEU192

site_idSWS_FT_FI6
Number of Residues80
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000250|UniProtKB:O60741
ChainResidueDetails
CLYS202-LEU222
ALYS202-LEU222
BLYS202-LEU222
DLYS202-LEU222

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000250|UniProtKB:O60741
ChainResidueDetails
CLEU254-MET274
ALEU254-MET274
BLEU254-MET274
DLEU254-MET274

site_idSWS_FT_FI8
Number of Residues84
DetailsINTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000250|UniProtKB:O60741
ChainResidueDetails
CTYR298-PRO319
ATYR298-PRO319
BTYR298-PRO319
DTYR298-PRO319

site_idSWS_FT_FI9
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000250|UniProtKB:O60741
ChainResidueDetails
CLEU330-ILE350
ALEU330-ILE350
BLEU330-ILE350
DLEU330-ILE350

site_idSWS_FT_FI10
Number of Residues24
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:O60741
ChainResidueDetails
CGLY492
AARG502
ATHR503
AARG546
BGLY492
BGLU493
BCYS495
BARG502
BTHR503
BARG546
DGLY492
CGLU493
DGLU493
DCYS495
DARG502
DTHR503
DARG546
CCYS495
CARG502
CTHR503
CARG546
AGLY492
AGLU493
ACYS495

site_idSWS_FT_FI11
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:O88704
ChainResidueDetails
CARG543
AARG543
BARG543
DARG543

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O88705
ChainResidueDetails
CSER634
ASER634
BSER634
DSER634

site_idSWS_FT_FI13
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN291
AASN291
BASN291
DASN291

229183

PDB entries from 2024-12-18

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