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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8IO3

Cryo-EM structure of human HCN3 channel with cilobradine

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003254biological_processregulation of membrane depolarization
A0005216molecular_functionmonoatomic ion channel activity
A0005248molecular_functionvoltage-gated sodium channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005272molecular_functionsodium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006814biological_processsodium ion transport
A0016020cellular_componentmembrane
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030552molecular_functioncAMP binding
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0035725biological_processsodium ion transmembrane transport
A0042391biological_processregulation of membrane potential
A0055085biological_processtransmembrane transport
A0071320biological_processcellular response to cAMP
A0071805biological_processpotassium ion transmembrane transport
A0086091biological_processregulation of heart rate by cardiac conduction
A0098719biological_processsodium ion import across plasma membrane
A0098855cellular_componentHCN channel complex
A0098907biological_processregulation of SA node cell action potential
A1990573biological_processpotassium ion import across plasma membrane
B0000166molecular_functionnucleotide binding
B0003254biological_processregulation of membrane depolarization
B0005216molecular_functionmonoatomic ion channel activity
B0005248molecular_functionvoltage-gated sodium channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005272molecular_functionsodium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006814biological_processsodium ion transport
B0016020cellular_componentmembrane
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030552molecular_functioncAMP binding
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0035725biological_processsodium ion transmembrane transport
B0042391biological_processregulation of membrane potential
B0055085biological_processtransmembrane transport
B0071320biological_processcellular response to cAMP
B0071805biological_processpotassium ion transmembrane transport
B0086091biological_processregulation of heart rate by cardiac conduction
B0098719biological_processsodium ion import across plasma membrane
B0098855cellular_componentHCN channel complex
B0098907biological_processregulation of SA node cell action potential
B1990573biological_processpotassium ion import across plasma membrane
C0000166molecular_functionnucleotide binding
C0003254biological_processregulation of membrane depolarization
C0005216molecular_functionmonoatomic ion channel activity
C0005248molecular_functionvoltage-gated sodium channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005272molecular_functionsodium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006814biological_processsodium ion transport
C0016020cellular_componentmembrane
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0030552molecular_functioncAMP binding
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0035725biological_processsodium ion transmembrane transport
C0042391biological_processregulation of membrane potential
C0055085biological_processtransmembrane transport
C0071320biological_processcellular response to cAMP
C0071805biological_processpotassium ion transmembrane transport
C0086091biological_processregulation of heart rate by cardiac conduction
C0098719biological_processsodium ion import across plasma membrane
C0098855cellular_componentHCN channel complex
C0098907biological_processregulation of SA node cell action potential
C1990573biological_processpotassium ion import across plasma membrane
D0000166molecular_functionnucleotide binding
D0003254biological_processregulation of membrane depolarization
D0005216molecular_functionmonoatomic ion channel activity
D0005248molecular_functionvoltage-gated sodium channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005272molecular_functionsodium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006814biological_processsodium ion transport
D0016020cellular_componentmembrane
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0030552molecular_functioncAMP binding
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0035725biological_processsodium ion transmembrane transport
D0042391biological_processregulation of membrane potential
D0055085biological_processtransmembrane transport
D0071320biological_processcellular response to cAMP
D0071805biological_processpotassium ion transmembrane transport
D0086091biological_processregulation of heart rate by cardiac conduction
D0098719biological_processsodium ion import across plasma membrane
D0098855cellular_componentHCN channel complex
D0098907biological_processregulation of SA node cell action potential
D1990573biological_processpotassium ion import across plasma membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"UniProtKB","id":"O60741","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues144
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"O60741","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"UniProtKB","id":"O60741","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues120
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"O60741","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"UniProtKB","id":"O60741","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues84
DetailsIntramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"source":"UniProtKB","id":"O60741","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"UniProtKB","id":"O60741","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"O60741","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

244693

PDB entries from 2025-11-12

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