8D5B

Crystal structure of human METTL1 in complex with SAH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	tRNA (guanine-N(7)-)-methyltransferase	polymer	262	30412.7	1	UniProt (Q9UBP6) Pfam (PF02390) In PDB	Homo sapiens (human)	Methyltransferase-like protein 1,mRNA (guanine-N(7)-)-methyltransferase,miRNA (guanine-N(7)-)-methyltransferase,tRNA (guanine(46)-N(7))-methyltransferase,tRNA(m7G46)-methyltransferase
2	A	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH)
3	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6	A	CACODYLATE ION	non-polymer		137.0	1	Chemie (CAC)
7		water	water		18.0	144	Chemie (HOH)

Sequence modifications

A: 20 - 265 (UniProt: Q9UBP6)

PDB	External Database	Details
Met 4	-	initiating methionine
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Glu 11	-	expression tag
Asn 12	-	expression tag
Leu 13	-	expression tag
Tyr 14	-	expression tag
Phe 15	-	expression tag
Gln 16	-	expression tag
Gly 17	-	expression tag
Ser 18	-	expression tag
Gly 19	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	30412.7
Non-Polymers*	Number of molecules	7
	Total formula weight	933.2
All*	Total formula weight	31345.9

*Water molecules are not included.