8D5B

Crystal structure of human METTL1 in complex with SAH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006400	biological_process	tRNA modification
A	0008176	molecular_function	tRNA (guanine(46)-N7)-methyltransferase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:36599982, ECO:0000305|PubMed:36599985

Chain	Residue	Details
A	ASP163

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:36599982, ECO:0000269|Ref.19, ECO:0007744|PDB:3CKK, ECO:0007744|PDB:8D9L

Chain	Residue	Details
A	GLY84
A	GLU107
A	ASN140
A	THR238

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:36599985, ECO:0007744|PDB:8CTH

Chain	Residue	Details
A	ILE108

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|Ref.19, ECO:0007744|PDB:3CKK

Chain	Residue	Details
A	ARG109
A	ALA141
A	LEU160
A	GLU240

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKB/AKT1 and RPS6KA3 => ECO:0000269|PubMed:15861136, ECO:0000269|PubMed:36599985, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER27

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