8BAH

Human Mre11-Nbs1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Double-strand break repair protein MRE11	polymer	738	84008.6	2	UniProt (P49959) Pfam (PF00149) Pfam (PF04152) In PDB	Homo sapiens (human)	Double-strand break repair protein MRE11A,Meiotic recombination 11 homolog 1,MRE11 homolog 1,Meiotic recombination 11 homolog A,MRE11 homolog A
2	C	Nibrin	polymer	754	85073.0	1	UniProt (O60934) Pfam (PF00498) Pfam (PF00533) Pfam (PF16508) Pfam (PF08599) In PDB	Homo sapiens (human)	Cell cycle regulatory protein p95,Nijmegen breakage syndrome protein 1
3	A, B	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)

Sequence modifications

A, B: 1 - 708 (UniProt: P49959)

PDB	External Database	Details
Asn 129	His 129	engineered mutation
Ser 709	-	expression tag
Gly 710	-	expression tag
Gly 711	-	expression tag
Ser 712	-	expression tag
Leu 713	-	expression tag
Glu 714	-	expression tag
Val 715	-	expression tag
Leu 716	-	expression tag
Phe 717	-	expression tag
Gln 718	-	expression tag
Gly 719	-	expression tag
Pro 720	-	expression tag
Asp 721	-	expression tag
Tyr 722	-	expression tag
Lys 723	-	expression tag
Asp 724	-	expression tag
Asp 725	-	expression tag
Asp 726	-	expression tag
Asp 727	-	expression tag
Lys 728	-	expression tag
Gly 729	-	expression tag
Thr 730	-	expression tag
Asp 731	-	expression tag
Tyr 732	-	expression tag
Lys 733	-	expression tag
Asp 734	-	expression tag
Asp 735	-	expression tag
Asp 736	-	expression tag
Asp 737	-	expression tag
Lys 738	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	253090.3
Non-Polymers*	Number of molecules	4
	Total formula weight	219.8
All*	Total formula weight	253310.0

*Water molecules are not included.