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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8BAH

Human Mre11-Nbs1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000014molecular_functionsingle-stranded DNA endodeoxyribonuclease activity
A0000019biological_processregulation of mitotic recombination
A0000723biological_processtelomere maintenance
A0000724biological_processdouble-strand break repair via homologous recombination
A0000729biological_processDNA double-strand break processing
A0000781cellular_componentchromosome, telomeric region
A0003677molecular_functionDNA binding
A0003678molecular_functionDNA helicase activity
A0003690molecular_functiondouble-stranded DNA binding
A0004518molecular_functionnuclease activity
A0004519molecular_functionendonuclease activity
A0004520molecular_functionDNA endonuclease activity
A0004527molecular_functionexonuclease activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005657cellular_componentreplication fork
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006281biological_processDNA repair
A0006302biological_processdouble-strand break repair
A0006303biological_processdouble-strand break repair via nonhomologous end joining
A0006310biological_processDNA recombination
A0006974biological_processDNA damage response
A0007004biological_processtelomere maintenance via telomerase
A0007062biological_processsister chromatid cohesion
A0007095biological_processmitotic G2 DNA damage checkpoint signaling
A0007131biological_processreciprocal meiotic recombination
A0008296molecular_function3'-5'-DNA exonuclease activity
A0008408molecular_function3'-5' exonuclease activity
A0016605cellular_componentPML body
A0016787molecular_functionhydrolase activity
A0030145molecular_functionmanganese ion binding
A0030870cellular_componentMre11 complex
A0031573biological_processmitotic intra-S DNA damage checkpoint signaling
A0031860biological_processtelomeric 3' overhang formation
A0032206biological_processpositive regulation of telomere maintenance
A0035825biological_processhomologous recombination
A0035861cellular_componentsite of double-strand break
A0042138biological_processmeiotic DNA double-strand break formation
A0042802molecular_functionidentical protein binding
A0043066biological_processnegative regulation of apoptotic process
A0044818biological_processmitotic G2/M transition checkpoint
A0045296molecular_functioncadherin binding
A0051276biological_processchromosome organization
A0051321biological_processmeiotic cell cycle
A0062176biological_processR-loop processing
A0097552biological_processmitochondrial double-strand break repair via homologous recombination
A0098687cellular_componentchromosomal region
A0110025biological_processDNA strand resection involved in replication fork processing
A2000781biological_processpositive regulation of double-strand break repair
A2001033biological_processnegative regulation of double-strand break repair via nonhomologous end joining
B0000014molecular_functionsingle-stranded DNA endodeoxyribonuclease activity
B0000019biological_processregulation of mitotic recombination
B0000723biological_processtelomere maintenance
B0000724biological_processdouble-strand break repair via homologous recombination
B0000729biological_processDNA double-strand break processing
B0000781cellular_componentchromosome, telomeric region
B0003677molecular_functionDNA binding
B0003678molecular_functionDNA helicase activity
B0003690molecular_functiondouble-stranded DNA binding
B0004518molecular_functionnuclease activity
B0004519molecular_functionendonuclease activity
B0004520molecular_functionDNA endonuclease activity
B0004527molecular_functionexonuclease activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005657cellular_componentreplication fork
B0005694cellular_componentchromosome
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006281biological_processDNA repair
B0006302biological_processdouble-strand break repair
B0006303biological_processdouble-strand break repair via nonhomologous end joining
B0006310biological_processDNA recombination
B0006974biological_processDNA damage response
B0007004biological_processtelomere maintenance via telomerase
B0007062biological_processsister chromatid cohesion
B0007095biological_processmitotic G2 DNA damage checkpoint signaling
B0007131biological_processreciprocal meiotic recombination
B0008296molecular_function3'-5'-DNA exonuclease activity
B0008408molecular_function3'-5' exonuclease activity
B0016605cellular_componentPML body
B0016787molecular_functionhydrolase activity
B0030145molecular_functionmanganese ion binding
B0030870cellular_componentMre11 complex
B0031573biological_processmitotic intra-S DNA damage checkpoint signaling
B0031860biological_processtelomeric 3' overhang formation
B0032206biological_processpositive regulation of telomere maintenance
B0035825biological_processhomologous recombination
B0035861cellular_componentsite of double-strand break
B0042138biological_processmeiotic DNA double-strand break formation
B0042802molecular_functionidentical protein binding
B0043066biological_processnegative regulation of apoptotic process
B0044818biological_processmitotic G2/M transition checkpoint
B0045296molecular_functioncadherin binding
B0051276biological_processchromosome organization
B0051321biological_processmeiotic cell cycle
B0062176biological_processR-loop processing
B0097552biological_processmitochondrial double-strand break repair via homologous recombination
B0098687cellular_componentchromosomal region
B0110025biological_processDNA strand resection involved in replication fork processing
B2000781biological_processpositive regulation of double-strand break repair
B2001033biological_processnegative regulation of double-strand break repair via nonhomologous end joining
C0000077biological_processDNA damage checkpoint signaling
C0000723biological_processtelomere maintenance
C0000724biological_processdouble-strand break repair via homologous recombination
C0000729biological_processDNA double-strand break processing
C0000781cellular_componentchromosome, telomeric region
C0001701biological_processin utero embryonic development
C0001832biological_processblastocyst growth
C0003684molecular_functiondamaged DNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005657cellular_componentreplication fork
C0005694cellular_componentchromosome
C0005730cellular_componentnucleolus
C0005829cellular_componentcytosol
C0006281biological_processDNA repair
C0006302biological_processdouble-strand break repair
C0006974biological_processDNA damage response
C0007093biological_processmitotic cell cycle checkpoint signaling
C0007095biological_processmitotic G2 DNA damage checkpoint signaling
C0016605cellular_componentPML body
C0030174biological_processregulation of DNA-templated DNA replication initiation
C0030330biological_processDNA damage response, signal transduction by p53 class mediator
C0030870cellular_componentMre11 complex
C0031848biological_processprotection from non-homologous end joining at telomere
C0031860biological_processtelomeric 3' overhang formation
C0032206biological_processpositive regulation of telomere maintenance
C0035825biological_processhomologous recombination
C0035861cellular_componentsite of double-strand break
C0042393molecular_functionhistone binding
C0042405cellular_componentnuclear inclusion body
C0043247biological_processtelomere maintenance in response to DNA damage
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0044818biological_processmitotic G2/M transition checkpoint
C0045190biological_processisotype switching
C0051321biological_processmeiotic cell cycle
C0051726biological_processregulation of cell cycle
C0062176biological_processR-loop processing
C0070534biological_processprotein K63-linked ubiquitination
C0090656biological_processt-circle formation
C0090737biological_processtelomere maintenance via telomere trimming
C0097681biological_processdouble-strand break repair via alternative nonhomologous end joining
C0098687cellular_componentchromosomal region
C0110025biological_processDNA strand resection involved in replication fork processing
C0140031molecular_functionphosphorylation-dependent protein binding
C0140297molecular_functionDNA-binding transcription factor binding
C0140463molecular_functionchromatin-protein adaptor activity
C1904354biological_processnegative regulation of telomere capping
C1905168biological_processpositive regulation of double-strand break repair via homologous recombination
C1990166biological_processprotein localization to site of double-strand break
C2000781biological_processpositive regulation of double-strand break repair
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues60
DetailsRegion: {"description":"Interaction with NBN","evidences":[{"source":"PubMed","id":"22078559","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q61216","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22078559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36577401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T1I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8BAH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q61216","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"36050397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"36050397","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36563124","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues3
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"30952868","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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