7ZNL

Structure of the human TREX core THO-UAP56 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, I, a, i	THO complex subunit 1	polymer	657	75752.2	4	UniProt (Q96FV9) Pfam (PF11957) Pfam (PF00531) In PDB	Homo sapiens (human)	Tho1,Nuclear matrix protein p84,p84N5,hTREX84
2	B, J, b, j	THO complex subunit 2	polymer	1593	183087.7	4	UniProt (Q8NI27) Pfam (PF16134) Pfam (PF11732) Pfam (PF11262) In PDB	Homo sapiens (human)	Tho2,hTREX120
3	C, K, c, k	THO complex subunit 3	polymer	351	38817.6	4	UniProt (Q96J01) Pfam (PF00400) Pfam (PF12894) Pfam (PF07676) In PDB	Homo sapiens (human)	Tho3,TEX1 homolog,hTREX45
4	E, M, e, m	THO complex subunit 5 homolog	polymer	683	78624.9	4	UniProt (Q13769) Pfam (PF09766) In PDB	Homo sapiens (human)	Functional spliceosome-associated protein 79,fSAP79,NF2/meningioma region protein pK1.3,Placental protein 39.2,PP39.2,hTREX90
5	F, N, f, n	THO complex subunit 6 homolog	polymer	341	37577.9	4	UniProt (Q86W42) Pfam (PF00400) In PDB	Homo sapiens (human)	Functional spliceosome-associated protein 35,fSAP35,WD repeat-containing protein 58
6	G, O, g, o	THO complex subunit 7 homolog	polymer	204	23782.0	4	UniProt (Q6I9Y2) Pfam (PF05615) In PDB	Homo sapiens (human)	Functional spliceosome-associated protein 24,fSAP24,Ngg1-interacting factor 3-like protein 1-binding protein 1,NIF3L1-binding protein 1,hTREX30
7	H, P, h, p	Spliceosome RNA helicase DDX39B	polymer	428	49056.3	4	UniProt (Q13838) Pfam (PF00270) Pfam (PF00271) In PDB	Homo sapiens (human)	56 kDa U2AF65-associated protein,ATP-dependent RNA helicase p47,DEAD box protein UAP56,HLA-B-associated transcript 1 protein

Contents of the asymmetric unit

Polymers	Number of chains	28
	Total formula weight	1946794.0
All*	Total formula weight	1946794.0

*Water molecules are not included.