7ZNL

Structure of the human TREX core THO-UAP56 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, H, O, V (A, I, a, i)	THO complex subunit 1	polymer	657	75752.2	4	UniProt (Q96FV9) Pfam (PF11957) Pfam (PF00531)	Homo sapiens (human)	Tho1,Nuclear matrix protein p84,p84N5,hTREX84
2	B, I, P, W (B, J, b, j)	THO complex subunit 2	polymer	1593	183087.7	4	UniProt (Q8NI27) Pfam (PF16134) Pfam (PF11732) Pfam (PF11262)	Homo sapiens (human)	Tho2,hTREX120
3	C, J, Q, X (C, K, c, k)	THO complex subunit 3	polymer	351	38817.6	4	UniProt (Q96J01) Pfam (PF25174)	Homo sapiens (human)	Tho3,TEX1 homolog,hTREX45
4	D, K, R, Y (E, M, e, m)	THO complex subunit 5 homolog	polymer	683	78624.9	4	UniProt (Q13769) Pfam (PF09766)	Homo sapiens (human)	Functional spliceosome-associated protein 79,fSAP79,NF2/meningioma region protein pK1.3,Placental protein 39.2,PP39.2,hTREX90
5	E, L, S, Z (F, N, f, n)	THO complex subunit 6 homolog	polymer	341	37577.9	4	UniProt (Q86W42) Pfam (PF00400)	Homo sapiens (human)	Functional spliceosome-associated protein 35,fSAP35,WD repeat-containing protein 58
6	AA, F, M, T (G, O, g, o)	THO complex subunit 7 homolog	polymer	204	23782.0	4	UniProt (Q6I9Y2) Pfam (PF05615)	Homo sapiens (human)	Functional spliceosome-associated protein 24,fSAP24,Ngg1-interacting factor 3-like protein 1-binding protein 1,NIF3L1-binding protein 1,hTREX30
7	BA, G, N, U (H, P, h, p)	Spliceosome RNA helicase DDX39B	polymer	428	49056.3	4	UniProt (Q13838) Pfam (PF00270) Pfam (PF00271)	Homo sapiens (human)	56 kDa U2AF65-associated protein,ATP-dependent RNA helicase p47,DEAD box protein UAP56,HLA-B-associated transcript 1 protein

Contents of the asymmetric unit

Polymers	Number of chains	28
	Total formula weight	1946794.0
All*	Total formula weight	1946794.0

*Water molecules are not included.