7ZNK
Structure of an endogenous human TREX complex bound to mRNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (2, 4) | RNA | polymer | 3 | 873.5 | 2 | Homo sapiens | ||
| 2 | C, J, R, Y (A, I, a, i) | THO complex subunit 1 | polymer | 657 | 75752.2 | 4 | UniProt (Q96FV9) Pfam (PF11957) Pfam (PF00531) | Homo sapiens (human) | Tho1,Nuclear matrix protein p84,p84N5,hTREX84 |
| 3 | D, K, S, Z (B, J, b, j) | THO complex subunit 2 | polymer | 1593 | 183087.7 | 4 | UniProt (Q8NI27) Pfam (PF16134) Pfam (PF11732) Pfam (PF11262) | Homo sapiens (human) | Tho2,hTREX120 |
| 4 | AA, E, L, T (C, K, c, k) | THO complex subunit 3 | polymer | 351 | 38817.6 | 4 | UniProt (Q96J01) Pfam (PF00400) Pfam (PF12894) Pfam (PF07676) | Homo sapiens (human) | Tho3,TEX1 homolog,hTREX45 |
| 5 | CA, F, N, U (E, M, e, m) | THO complex subunit 5 homolog | polymer | 683 | 78652.9 | 4 | UniProt (Q13769) Pfam (PF09766) | Homo sapiens (human) | Functional spliceosome-associated protein 79,fSAP79,NF2/meningioma region protein pK1.3,Placental protein 39.2,PP39.2,hTREX90 |
| 6 | DA, G, O, V (F, N, f, n) | THO complex subunit 6 homolog | polymer | 341 | 37577.9 | 4 | UniProt (Q86W42) Pfam (PF00400) | Homo sapiens (human) | Functional spliceosome-associated protein 35,fSAP35,WD repeat-containing protein 58 |
| 7 | EA, H, P, W (G, O, g, o) | THO complex subunit 7 homolog | polymer | 204 | 23782.0 | 4 | UniProt (Q6I9Y2) Pfam (PF05615) | Homo sapiens (human) | Functional spliceosome-associated protein 24,fSAP24,Ngg1-interacting factor 3-like protein 1-binding protein 1,NIF3L1-binding protein 1,hTREX30 |
| 8 | FA, I, Q, X (H, P, h, p) | Spliceosome RNA helicase DDX39B | polymer | 428 | 49056.3 | 4 | UniProt (Q13838) Pfam (PF00270) Pfam (PF00271) | Homo sapiens (human) | 56 kDa U2AF65-associated protein,ATP-dependent RNA helicase p47,DEAD box protein UAP56,HLA-B-associated transcript 1 protein |
| 9 | BA, M (L, l) | THO complex subunit 4 | polymer | 257 | 26934.0 | 2 | UniProt (Q86V81) Pfam (PF00076) Pfam (PF13865) | Homo sapiens (human) | Tho4,Ally of AML-1 and LEF-1,Aly/REF export factor,Transcriptional coactivator Aly/REF,bZIP-enhancing factor BEF |
Sequence modifications
E, M, e, m: 1 - 683 (UniProt: Q13769)
| PDB | External Database | Details |
|---|---|---|
| Ile 525 | Val 525 | conflict |
| Ile 579 | Val 579 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 32 |
| Total formula weight | 2002521.3 | |
| All* | Total formula weight | 2002521.3 |
