7ZNK

Structure of an endogenous human TREX complex bound to mRNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000346	cellular_component	transcription export complex
A	0000347	cellular_component	THO complex
A	0000445	cellular_component	THO complex part of transcription export complex
A	0000781	cellular_component	chromosome, telomeric region
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0006397	biological_process	mRNA processing
A	0006406	biological_process	mRNA export from nucleus
A	0006915	biological_process	apoptotic process
A	0007165	biological_process	signal transduction
A	0008380	biological_process	RNA splicing
A	0016363	cellular_component	nuclear matrix
A	0016607	cellular_component	nuclear speck
A	0042802	molecular_function	identical protein binding
A	0051028	biological_process	mRNA transport
B	0000346	cellular_component	transcription export complex
B	0000347	cellular_component	THO complex
B	0000445	cellular_component	THO complex part of transcription export complex
B	0000781	cellular_component	chromosome, telomeric region
B	0000902	biological_process	cell morphogenesis
B	0001824	biological_process	blastocyst development
B	0003723	molecular_function	RNA binding
B	0003729	molecular_function	mRNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006397	biological_process	mRNA processing
B	0006406	biological_process	mRNA export from nucleus
B	0008380	biological_process	RNA splicing
B	0010468	biological_process	regulation of gene expression
B	0010793	biological_process	regulation of mRNA export from nucleus
B	0010977	biological_process	negative regulation of neuron projection development
B	0016607	cellular_component	nuclear speck
B	0016973	biological_process	poly(A)+ mRNA export from nucleus
B	0017145	biological_process	stem cell division
B	0048666	biological_process	neuron development
B	0048699	biological_process	generation of neurons
B	0051028	biological_process	mRNA transport
C	0000346	cellular_component	transcription export complex
C	0000445	cellular_component	THO complex part of transcription export complex
C	0000781	cellular_component	chromosome, telomeric region
C	0003723	molecular_function	RNA binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0006397	biological_process	mRNA processing
C	0006406	biological_process	mRNA export from nucleus
C	0008380	biological_process	RNA splicing
C	0016607	cellular_component	nuclear speck
C	0051028	biological_process	mRNA transport
E	0000346	cellular_component	transcription export complex
E	0000347	cellular_component	THO complex
E	0000445	cellular_component	THO complex part of transcription export complex
E	0000781	cellular_component	chromosome, telomeric region
E	0003723	molecular_function	RNA binding
E	0003729	molecular_function	mRNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0006397	biological_process	mRNA processing
E	0006406	biological_process	mRNA export from nucleus
E	0008380	biological_process	RNA splicing
E	0030154	biological_process	cell differentiation
E	0030224	biological_process	monocyte differentiation
E	0051028	biological_process	mRNA transport
E	0060215	biological_process	primitive hemopoiesis
F	0000346	cellular_component	transcription export complex
F	0000347	cellular_component	THO complex
F	0000445	cellular_component	THO complex part of transcription export complex
F	0000781	cellular_component	chromosome, telomeric region
F	0003723	molecular_function	RNA binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0006397	biological_process	mRNA processing
F	0006406	biological_process	mRNA export from nucleus
F	0006915	biological_process	apoptotic process
F	0007417	biological_process	central nervous system development
F	0008380	biological_process	RNA splicing
F	0016604	cellular_component	nuclear body
F	0016607	cellular_component	nuclear speck
F	0051028	biological_process	mRNA transport
G	0000346	cellular_component	transcription export complex
G	0000347	cellular_component	THO complex
G	0000445	cellular_component	THO complex part of transcription export complex
G	0000781	cellular_component	chromosome, telomeric region
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006397	biological_process	mRNA processing
G	0006406	biological_process	mRNA export from nucleus
G	0008380	biological_process	RNA splicing
G	0016607	cellular_component	nuclear speck
G	0051028	biological_process	mRNA transport
H	0000166	molecular_function	nucleotide binding
H	0000245	biological_process	spliceosomal complex assembly
H	0000346	cellular_component	transcription export complex
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0003676	molecular_function	nucleic acid binding
H	0003723	molecular_function	RNA binding
H	0003724	molecular_function	RNA helicase activity
H	0003729	molecular_function	mRNA binding
H	0004386	molecular_function	helicase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005681	cellular_component	spliceosomal complex
H	0005687	cellular_component	U4 snRNP
H	0005688	cellular_component	U6 snRNP
H	0005737	cellular_component	cytoplasm
H	0006397	biological_process	mRNA processing
H	0006405	biological_process	RNA export from nucleus
H	0006406	biological_process	mRNA export from nucleus
H	0008186	molecular_function	ATP-dependent activity, acting on RNA
H	0008380	biological_process	RNA splicing
H	0016607	cellular_component	nuclear speck
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0017070	molecular_function	U6 snRNA binding
H	0030621	molecular_function	U4 snRNA binding
H	0042802	molecular_function	identical protein binding
H	0043008	molecular_function	ATP-dependent protein binding
H	0051028	biological_process	mRNA transport
I	0000346	cellular_component	transcription export complex
I	0000347	cellular_component	THO complex
I	0000445	cellular_component	THO complex part of transcription export complex
I	0000781	cellular_component	chromosome, telomeric region
I	0003677	molecular_function	DNA binding
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0006397	biological_process	mRNA processing
I	0006406	biological_process	mRNA export from nucleus
I	0006915	biological_process	apoptotic process
I	0007165	biological_process	signal transduction
I	0008380	biological_process	RNA splicing
I	0016363	cellular_component	nuclear matrix
I	0016607	cellular_component	nuclear speck
I	0042802	molecular_function	identical protein binding
I	0051028	biological_process	mRNA transport
J	0000346	cellular_component	transcription export complex
J	0000347	cellular_component	THO complex
J	0000445	cellular_component	THO complex part of transcription export complex
J	0000781	cellular_component	chromosome, telomeric region
J	0000902	biological_process	cell morphogenesis
J	0001824	biological_process	blastocyst development
J	0003723	molecular_function	RNA binding
J	0003729	molecular_function	mRNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0006397	biological_process	mRNA processing
J	0006406	biological_process	mRNA export from nucleus
J	0008380	biological_process	RNA splicing
J	0010468	biological_process	regulation of gene expression
J	0010793	biological_process	regulation of mRNA export from nucleus
J	0010977	biological_process	negative regulation of neuron projection development
J	0016607	cellular_component	nuclear speck
J	0016973	biological_process	poly(A)+ mRNA export from nucleus
J	0017145	biological_process	stem cell division
J	0048666	biological_process	neuron development
J	0048699	biological_process	generation of neurons
J	0051028	biological_process	mRNA transport
K	0000346	cellular_component	transcription export complex
K	0000445	cellular_component	THO complex part of transcription export complex
K	0000781	cellular_component	chromosome, telomeric region
K	0003723	molecular_function	RNA binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0006397	biological_process	mRNA processing
K	0006406	biological_process	mRNA export from nucleus
K	0008380	biological_process	RNA splicing
K	0016607	cellular_component	nuclear speck
K	0051028	biological_process	mRNA transport
L	0000346	cellular_component	transcription export complex
L	0000781	cellular_component	chromosome, telomeric region
L	0001649	biological_process	osteoblast differentiation
L	0003676	molecular_function	nucleic acid binding
L	0003723	molecular_function	RNA binding
L	0003729	molecular_function	mRNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005681	cellular_component	spliceosomal complex
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006397	biological_process	mRNA processing
L	0006405	biological_process	RNA export from nucleus
L	0006406	biological_process	mRNA export from nucleus
L	0008380	biological_process	RNA splicing
L	0016020	cellular_component	membrane
L	0016607	cellular_component	nuclear speck
L	0035145	cellular_component	exon-exon junction complex
L	0051028	biological_process	mRNA transport
L	0062153	molecular_function	C5-methylcytidine-containing RNA reader activity
L	0070062	cellular_component	extracellular exosome
L	0071013	cellular_component	catalytic step 2 spliceosome
M	0000346	cellular_component	transcription export complex
M	0000347	cellular_component	THO complex
M	0000445	cellular_component	THO complex part of transcription export complex
M	0000781	cellular_component	chromosome, telomeric region
M	0003723	molecular_function	RNA binding
M	0003729	molecular_function	mRNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0006397	biological_process	mRNA processing
M	0006406	biological_process	mRNA export from nucleus
M	0008380	biological_process	RNA splicing
M	0030154	biological_process	cell differentiation
M	0030224	biological_process	monocyte differentiation
M	0051028	biological_process	mRNA transport
M	0060215	biological_process	primitive hemopoiesis
N	0000346	cellular_component	transcription export complex
N	0000347	cellular_component	THO complex
N	0000445	cellular_component	THO complex part of transcription export complex
N	0000781	cellular_component	chromosome, telomeric region
N	0003723	molecular_function	RNA binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0006397	biological_process	mRNA processing
N	0006406	biological_process	mRNA export from nucleus
N	0006915	biological_process	apoptotic process
N	0007417	biological_process	central nervous system development
N	0008380	biological_process	RNA splicing
N	0016604	cellular_component	nuclear body
N	0016607	cellular_component	nuclear speck
N	0051028	biological_process	mRNA transport
O	0000346	cellular_component	transcription export complex
O	0000347	cellular_component	THO complex
O	0000445	cellular_component	THO complex part of transcription export complex
O	0000781	cellular_component	chromosome, telomeric region
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006397	biological_process	mRNA processing
O	0006406	biological_process	mRNA export from nucleus
O	0008380	biological_process	RNA splicing
O	0016607	cellular_component	nuclear speck
O	0051028	biological_process	mRNA transport
P	0000166	molecular_function	nucleotide binding
P	0000245	biological_process	spliceosomal complex assembly
P	0000346	cellular_component	transcription export complex
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0003676	molecular_function	nucleic acid binding
P	0003723	molecular_function	RNA binding
P	0003724	molecular_function	RNA helicase activity
P	0003729	molecular_function	mRNA binding
P	0004386	molecular_function	helicase activity
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005681	cellular_component	spliceosomal complex
P	0005687	cellular_component	U4 snRNP
P	0005688	cellular_component	U6 snRNP
P	0005737	cellular_component	cytoplasm
P	0006397	biological_process	mRNA processing
P	0006405	biological_process	RNA export from nucleus
P	0006406	biological_process	mRNA export from nucleus
P	0008186	molecular_function	ATP-dependent activity, acting on RNA
P	0008380	biological_process	RNA splicing
P	0016607	cellular_component	nuclear speck
P	0016787	molecular_function	hydrolase activity
P	0016887	molecular_function	ATP hydrolysis activity
P	0017070	molecular_function	U6 snRNA binding
P	0030621	molecular_function	U4 snRNA binding
P	0042802	molecular_function	identical protein binding
P	0043008	molecular_function	ATP-dependent protein binding
P	0051028	biological_process	mRNA transport
a	0000346	cellular_component	transcription export complex
a	0000347	cellular_component	THO complex
a	0000445	cellular_component	THO complex part of transcription export complex
a	0000781	cellular_component	chromosome, telomeric region
a	0003677	molecular_function	DNA binding
a	0003723	molecular_function	RNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005737	cellular_component	cytoplasm
a	0006397	biological_process	mRNA processing
a	0006406	biological_process	mRNA export from nucleus
a	0006915	biological_process	apoptotic process
a	0007165	biological_process	signal transduction
a	0008380	biological_process	RNA splicing
a	0016363	cellular_component	nuclear matrix
a	0016607	cellular_component	nuclear speck
a	0042802	molecular_function	identical protein binding
a	0051028	biological_process	mRNA transport
b	0000346	cellular_component	transcription export complex
b	0000347	cellular_component	THO complex
b	0000445	cellular_component	THO complex part of transcription export complex
b	0000781	cellular_component	chromosome, telomeric region
b	0000902	biological_process	cell morphogenesis
b	0001824	biological_process	blastocyst development
b	0003723	molecular_function	RNA binding
b	0003729	molecular_function	mRNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005737	cellular_component	cytoplasm
b	0006397	biological_process	mRNA processing
b	0006406	biological_process	mRNA export from nucleus
b	0008380	biological_process	RNA splicing
b	0010468	biological_process	regulation of gene expression
b	0010793	biological_process	regulation of mRNA export from nucleus
b	0010977	biological_process	negative regulation of neuron projection development
b	0016607	cellular_component	nuclear speck
b	0016973	biological_process	poly(A)+ mRNA export from nucleus
b	0017145	biological_process	stem cell division
b	0048666	biological_process	neuron development
b	0048699	biological_process	generation of neurons
b	0051028	biological_process	mRNA transport
c	0000346	cellular_component	transcription export complex
c	0000445	cellular_component	THO complex part of transcription export complex
c	0000781	cellular_component	chromosome, telomeric region
c	0003723	molecular_function	RNA binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0006397	biological_process	mRNA processing
c	0006406	biological_process	mRNA export from nucleus
c	0008380	biological_process	RNA splicing
c	0016607	cellular_component	nuclear speck
c	0051028	biological_process	mRNA transport
e	0000346	cellular_component	transcription export complex
e	0000347	cellular_component	THO complex
e	0000445	cellular_component	THO complex part of transcription export complex
e	0000781	cellular_component	chromosome, telomeric region
e	0003723	molecular_function	RNA binding
e	0003729	molecular_function	mRNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005737	cellular_component	cytoplasm
e	0006397	biological_process	mRNA processing
e	0006406	biological_process	mRNA export from nucleus
e	0008380	biological_process	RNA splicing
e	0030154	biological_process	cell differentiation
e	0030224	biological_process	monocyte differentiation
e	0051028	biological_process	mRNA transport
e	0060215	biological_process	primitive hemopoiesis
f	0000346	cellular_component	transcription export complex
f	0000347	cellular_component	THO complex
f	0000445	cellular_component	THO complex part of transcription export complex
f	0000781	cellular_component	chromosome, telomeric region
f	0003723	molecular_function	RNA binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0006397	biological_process	mRNA processing
f	0006406	biological_process	mRNA export from nucleus
f	0006915	biological_process	apoptotic process
f	0007417	biological_process	central nervous system development
f	0008380	biological_process	RNA splicing
f	0016604	cellular_component	nuclear body
f	0016607	cellular_component	nuclear speck
f	0051028	biological_process	mRNA transport
g	0000346	cellular_component	transcription export complex
g	0000347	cellular_component	THO complex
g	0000445	cellular_component	THO complex part of transcription export complex
g	0000781	cellular_component	chromosome, telomeric region
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0006397	biological_process	mRNA processing
g	0006406	biological_process	mRNA export from nucleus
g	0008380	biological_process	RNA splicing
g	0016607	cellular_component	nuclear speck
g	0051028	biological_process	mRNA transport
h	0000166	molecular_function	nucleotide binding
h	0000245	biological_process	spliceosomal complex assembly
h	0000346	cellular_component	transcription export complex
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0003676	molecular_function	nucleic acid binding
h	0003723	molecular_function	RNA binding
h	0003724	molecular_function	RNA helicase activity
h	0003729	molecular_function	mRNA binding
h	0004386	molecular_function	helicase activity
h	0005515	molecular_function	protein binding
h	0005524	molecular_function	ATP binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005681	cellular_component	spliceosomal complex
h	0005687	cellular_component	U4 snRNP
h	0005688	cellular_component	U6 snRNP
h	0005737	cellular_component	cytoplasm
h	0006397	biological_process	mRNA processing
h	0006405	biological_process	RNA export from nucleus
h	0006406	biological_process	mRNA export from nucleus
h	0008186	molecular_function	ATP-dependent activity, acting on RNA
h	0008380	biological_process	RNA splicing
h	0016607	cellular_component	nuclear speck
h	0016787	molecular_function	hydrolase activity
h	0016887	molecular_function	ATP hydrolysis activity
h	0017070	molecular_function	U6 snRNA binding
h	0030621	molecular_function	U4 snRNA binding
h	0042802	molecular_function	identical protein binding
h	0043008	molecular_function	ATP-dependent protein binding
h	0051028	biological_process	mRNA transport
i	0000346	cellular_component	transcription export complex
i	0000347	cellular_component	THO complex
i	0000445	cellular_component	THO complex part of transcription export complex
i	0000781	cellular_component	chromosome, telomeric region
i	0003677	molecular_function	DNA binding
i	0003723	molecular_function	RNA binding
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005737	cellular_component	cytoplasm
i	0006397	biological_process	mRNA processing
i	0006406	biological_process	mRNA export from nucleus
i	0006915	biological_process	apoptotic process
i	0007165	biological_process	signal transduction
i	0008380	biological_process	RNA splicing
i	0016363	cellular_component	nuclear matrix
i	0016607	cellular_component	nuclear speck
i	0042802	molecular_function	identical protein binding
i	0051028	biological_process	mRNA transport
j	0000346	cellular_component	transcription export complex
j	0000347	cellular_component	THO complex
j	0000445	cellular_component	THO complex part of transcription export complex
j	0000781	cellular_component	chromosome, telomeric region
j	0000902	biological_process	cell morphogenesis
j	0001824	biological_process	blastocyst development
j	0003723	molecular_function	RNA binding
j	0003729	molecular_function	mRNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005737	cellular_component	cytoplasm
j	0006397	biological_process	mRNA processing
j	0006406	biological_process	mRNA export from nucleus
j	0008380	biological_process	RNA splicing
j	0010468	biological_process	regulation of gene expression
j	0010793	biological_process	regulation of mRNA export from nucleus
j	0010977	biological_process	negative regulation of neuron projection development
j	0016607	cellular_component	nuclear speck
j	0016973	biological_process	poly(A)+ mRNA export from nucleus
j	0017145	biological_process	stem cell division
j	0048666	biological_process	neuron development
j	0048699	biological_process	generation of neurons
j	0051028	biological_process	mRNA transport
k	0000346	cellular_component	transcription export complex
k	0000445	cellular_component	THO complex part of transcription export complex
k	0000781	cellular_component	chromosome, telomeric region
k	0003723	molecular_function	RNA binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0006397	biological_process	mRNA processing
k	0006406	biological_process	mRNA export from nucleus
k	0008380	biological_process	RNA splicing
k	0016607	cellular_component	nuclear speck
k	0051028	biological_process	mRNA transport
l	0000346	cellular_component	transcription export complex
l	0000781	cellular_component	chromosome, telomeric region
l	0001649	biological_process	osteoblast differentiation
l	0003676	molecular_function	nucleic acid binding
l	0003723	molecular_function	RNA binding
l	0003729	molecular_function	mRNA binding
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005681	cellular_component	spliceosomal complex
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0006397	biological_process	mRNA processing
l	0006405	biological_process	RNA export from nucleus
l	0006406	biological_process	mRNA export from nucleus
l	0008380	biological_process	RNA splicing
l	0016020	cellular_component	membrane
l	0016607	cellular_component	nuclear speck
l	0035145	cellular_component	exon-exon junction complex
l	0051028	biological_process	mRNA transport
l	0062153	molecular_function	C5-methylcytidine-containing RNA reader activity
l	0070062	cellular_component	extracellular exosome
l	0071013	cellular_component	catalytic step 2 spliceosome
m	0000346	cellular_component	transcription export complex
m	0000347	cellular_component	THO complex
m	0000445	cellular_component	THO complex part of transcription export complex
m	0000781	cellular_component	chromosome, telomeric region
m	0003723	molecular_function	RNA binding
m	0003729	molecular_function	mRNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005737	cellular_component	cytoplasm
m	0006397	biological_process	mRNA processing
m	0006406	biological_process	mRNA export from nucleus
m	0008380	biological_process	RNA splicing
m	0030154	biological_process	cell differentiation
m	0030224	biological_process	monocyte differentiation
m	0051028	biological_process	mRNA transport
m	0060215	biological_process	primitive hemopoiesis
n	0000346	cellular_component	transcription export complex
n	0000347	cellular_component	THO complex
n	0000445	cellular_component	THO complex part of transcription export complex
n	0000781	cellular_component	chromosome, telomeric region
n	0003723	molecular_function	RNA binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0006397	biological_process	mRNA processing
n	0006406	biological_process	mRNA export from nucleus
n	0006915	biological_process	apoptotic process
n	0007417	biological_process	central nervous system development
n	0008380	biological_process	RNA splicing
n	0016604	cellular_component	nuclear body
n	0016607	cellular_component	nuclear speck
n	0051028	biological_process	mRNA transport
o	0000346	cellular_component	transcription export complex
o	0000347	cellular_component	THO complex
o	0000445	cellular_component	THO complex part of transcription export complex
o	0000781	cellular_component	chromosome, telomeric region
o	0003723	molecular_function	RNA binding
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005737	cellular_component	cytoplasm
o	0005829	cellular_component	cytosol
o	0006397	biological_process	mRNA processing
o	0006406	biological_process	mRNA export from nucleus
o	0008380	biological_process	RNA splicing
o	0016607	cellular_component	nuclear speck
o	0051028	biological_process	mRNA transport
p	0000166	molecular_function	nucleotide binding
p	0000245	biological_process	spliceosomal complex assembly
p	0000346	cellular_component	transcription export complex
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0003676	molecular_function	nucleic acid binding
p	0003723	molecular_function	RNA binding
p	0003724	molecular_function	RNA helicase activity
p	0003729	molecular_function	mRNA binding
p	0004386	molecular_function	helicase activity
p	0005515	molecular_function	protein binding
p	0005524	molecular_function	ATP binding
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005681	cellular_component	spliceosomal complex
p	0005687	cellular_component	U4 snRNP
p	0005688	cellular_component	U6 snRNP
p	0005737	cellular_component	cytoplasm
p	0006397	biological_process	mRNA processing
p	0006405	biological_process	RNA export from nucleus
p	0006406	biological_process	mRNA export from nucleus
p	0008186	molecular_function	ATP-dependent activity, acting on RNA
p	0008380	biological_process	RNA splicing
p	0016607	cellular_component	nuclear speck
p	0016787	molecular_function	hydrolase activity
p	0016887	molecular_function	ATP hydrolysis activity
p	0017070	molecular_function	U6 snRNA binding
p	0030621	molecular_function	U4 snRNA binding
p	0042802	molecular_function	identical protein binding
p	0043008	molecular_function	ATP-dependent protein binding
p	0051028	biological_process	mRNA transport

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VLSGgeDgAVRLWDL

Chain	Residue	Details
n	VAL183-LEU197

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	136
Details	Region: {"description":"Dock domain; interaction with THOC2","evidences":[{"source":"PubMed","id":"33191911","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7APK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	320
Details	Repeat: {"description":"WD 1","evidences":[{"source":"PDB","id":"7APK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	312
Details	Repeat: {"description":"WD 2","evidences":[{"source":"PDB","id":"7APK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	279
Details	Repeat: {"description":"WD 3","evidences":[{"source":"PDB","id":"7APK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	320
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PDB","id":"7APK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	312
Details	Repeat: {"description":"WD 5","evidences":[{"source":"PDB","id":"7APK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	304
Details	Repeat: {"description":"WD 6","evidences":[{"source":"PDB","id":"7APK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"18373705","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23032722","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	176
Details	Repeat: {"description":"WD 7","evidences":[{"source":"PDB","id":"7APK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	174
Details	Region: {"description":"Interaction with THOC5","evidences":[{"source":"PubMed","id":"19059247","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	644
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	6
Details	Motif: {"description":"DECD box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	16
Details	Region: {"description":"C-terminal UAP56-binding motif","evidences":[{"source":"PubMed","id":"37020021","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---