7ZJ3

Structure of TRIM2 RING domain in complex with UBE2D1~Ub conjugate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (D, G, J, A)	Tripartite motif-containing protein 2	polymer	97	10769.6	4	UniProt (Q9C040) Pfam (PF13445)	Homo sapiens (human)	E3 ubiquitin-protein ligase TRIM2,RING finger protein 86,RING-type E3 ubiquitin transferase TRIM2
2	B, E, H, L (E, H, K, B)	Ubiquitin-conjugating enzyme E2 D1	polymer	150	16867.2	4	UniProt (P51668) Pfam (PF00179)	Homo sapiens (human)	(E3-independent) E2 ubiquitin-conjugating enzyme D1,E2 ubiquitin-conjugating enzyme D1,Stimulator of Fe transport,SFT,UBC4/5 homolog,UbcH5,Ubiquitin carrier protein D1,Ubiquitin-conjugating enzyme E2(17)KB 1,Ubiquitin-conjugating enzyme E2-17 kDa 1,Ubiquitin-protein ligase D1
3	C, F, I, K (F, I, L, C)	Polyubiquitin-C	polymer	80	8893.2	4	UniProt (P0CG48) Pfam (PF00240)	Homo sapiens (human)
4	M, N, O, P, Q... (D, G, J, A)	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
5	AA, BA, CA, DA, EA... (J, K, L, A, C...)	water	water		18.0	138	Chemie (HOH)

Sequence modifications

D, G, J, A: 2 - 95 (UniProt: Q9C040)

PDB	External Database	Details
Gly -1	-	expression tag
Pro 0	-	expression tag
Gly 1	-	expression tag

E, H, K, B: 2 - 146 (UniProt: P51668)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Leu -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag
Arg 22	Ser 22	engineered mutation
Lys 85	Cys 85	engineered mutation

F, I, L, C: 0 - 76 (UniProt: P0CG48)

PDB	External Database	Details
Gly -3	-	expression tag
Ala -2	-	expression tag
Met -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	146120.0
Non-Polymers*	Number of molecules	8
	Total formula weight	523.3
All*	Total formula weight	146643.3

*Water molecules are not included.