7ZJ3

Structure of TRIM2 RING domain in complex with UBE2D1~Ub conjugate

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000151	cellular_component	ubiquitin ligase complex
B	0000209	biological_process	protein polyubiquitination
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0019787	molecular_function	ubiquitin-like protein transferase activity
B	0030514	biological_process	negative regulation of BMP signaling pathway
B	0031398	biological_process	positive regulation of protein ubiquitination
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032991	cellular_component	protein-containing complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0061631	molecular_function	ubiquitin conjugating enzyme activity
B	0070936	biological_process	protein K48-linked ubiquitination
B	1902916	biological_process	positive regulation of protein polyubiquitination
B	1904262	biological_process	negative regulation of TORC1 signaling
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000151	cellular_component	ubiquitin ligase complex
E	0000209	biological_process	protein polyubiquitination
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0016567	biological_process	protein ubiquitination
E	0016740	molecular_function	transferase activity
E	0019787	molecular_function	ubiquitin-like protein transferase activity
E	0030514	biological_process	negative regulation of BMP signaling pathway
E	0031398	biological_process	positive regulation of protein ubiquitination
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032991	cellular_component	protein-containing complex
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0061630	molecular_function	ubiquitin protein ligase activity
E	0061631	molecular_function	ubiquitin conjugating enzyme activity
E	0070936	biological_process	protein K48-linked ubiquitination
E	1902916	biological_process	positive regulation of protein polyubiquitination
E	1904262	biological_process	negative regulation of TORC1 signaling
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000151	cellular_component	ubiquitin ligase complex
H	0000209	biological_process	protein polyubiquitination
H	0004842	molecular_function	ubiquitin-protein transferase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0016567	biological_process	protein ubiquitination
H	0016740	molecular_function	transferase activity
H	0019787	molecular_function	ubiquitin-like protein transferase activity
H	0030514	biological_process	negative regulation of BMP signaling pathway
H	0031398	biological_process	positive regulation of protein ubiquitination
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0032991	cellular_component	protein-containing complex
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0061631	molecular_function	ubiquitin conjugating enzyme activity
H	0070936	biological_process	protein K48-linked ubiquitination
H	1902916	biological_process	positive regulation of protein polyubiquitination
H	1904262	biological_process	negative regulation of TORC1 signaling
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0000151	cellular_component	ubiquitin ligase complex
K	0000209	biological_process	protein polyubiquitination
K	0004842	molecular_function	ubiquitin-protein transferase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0016567	biological_process	protein ubiquitination
K	0016740	molecular_function	transferase activity
K	0019787	molecular_function	ubiquitin-like protein transferase activity
K	0030514	biological_process	negative regulation of BMP signaling pathway
K	0031398	biological_process	positive regulation of protein ubiquitination
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0032991	cellular_component	protein-containing complex
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0061630	molecular_function	ubiquitin protein ligase activity
K	0061631	molecular_function	ubiquitin conjugating enzyme activity
K	0070936	biological_process	protein K48-linked ubiquitination
K	1902916	biological_process	positive regulation of protein polyubiquitination
K	1904262	biological_process	negative regulation of TORC1 signaling

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
F	LYS27-ASP52

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site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. ClHtFCerCL

Chain	Residue	Details
D	CYS38-LEU47

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742

Chain	Residue	Details
F	GLY0
I	GLY0
L	GLY0
C	GLY0

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site_id	SWS_FT_FI2
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
F	GLY0
G	SER10
I	GLY0
A	SER10
L	GLY0
C	GLY0

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