7Z3J

Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	polymer	1176	135990.9	1	UniProt (P10686) Pfam (PF00169) Pfam (PF00388) Pfam (PF00017) Pfam (PF00018) Pfam (PF00387) Pfam (PF00168)	Rattus norvegicus (Norway rat)	Phosphoinositide phospholipase C-gamma-1,Phospholipase C-gamma-1,PLC-gamma-1
2	B, C (A)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
3	D (A)	D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE	non-polymer		420.1	1	Chemie (I3P)
4	E, F, G (A)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
5	H (A)	water	water		18.0	243	Chemie (HOH)

Sequence modifications

A: 20 - null (UniProt: P10686)

PDB	External Database	Details
Ser 18	-	expression tag
Gln 19	-	expression tag
-	Thr 766	deletion
-	Ala 767	deletion
-	Glu 768	deletion
-	Pro 769	deletion
-	Asp 770	deletion
-	Tyr 771	deletion
-	Gly 772	deletion
-	Ala 773	deletion
-	Leu 774	deletion
-	Tyr 775	deletion
-	Glu 776	deletion
-	Gly 777	deletion
-	Arg 778	deletion
-	Asn 779	deletion
-	Pro 780	deletion
-	Gly 781	deletion
-	Phe 782	deletion
-	Tyr 783	deletion
-	Val 784	deletion
-	Glu 785	deletion
-	Ala 786	deletion
-	Asn 787	deletion
-	Pro 788	deletion
-	Met 789	deletion
-	Pro 790	deletion
Ser 766	-	linker
Gly 767	-	linker
Ser 768	-	linker

A: 791 - 1215 (UniProt: P10686)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	135990.9
Non-Polymers*	Number of molecules	6
	Total formula weight	776.5
All*	Total formula weight	136767.5

*Water molecules are not included.