7Z3J
Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004435 | molecular_function | phosphatidylinositol phospholipase C activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| A | 0009395 | biological_process | phospholipid catabolic process |
| A | 0035556 | biological_process | intracellular signal transduction |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DRNREDRISakDL |
| Chain | Residue | Details |
| A | ASP165-LEU177 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00270 |
| Chain | Residue | Details |
| A | HIS335 | |
| A | HIS380 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 |
| Chain | Residue | Details |
| A | ASP165 | |
| A | ASN167 | |
| A | GLU169 | |
| A | ARG171 | |
| A | ASP176 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q62077 |
| Chain | Residue | Details |
| A | TYR506 | |
| A | TYR977 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by SYK => ECO:0000250|UniProtKB:P08487 |
| Chain | Residue | Details |
| A | LYS793 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P19174 |
| Chain | Residue | Details |
| A | LYS797 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by ITK, SYK and TXK => ECO:0000250|UniProtKB:P19174 |
| Chain | Residue | Details |
| A | GLN805 |
