7Z3J

Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004435	molecular_function	phosphatidylinositol-4,5-bisphosphate phospholipase C activity
A	0005509	molecular_function	calcium ion binding
A	0006629	biological_process	lipid metabolic process
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
A	0009395	biological_process	phospholipid catabolic process
A	0035556	biological_process	intracellular signal transduction

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DRNREDRISakDL

Chain	Residue	Details
A	ASP165-LEU177

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00270

Chain	Residue	Details
A	HIS335
A	HIS380

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448

Chain	Residue	Details
A	ASP165
A	ASN167
A	GLU169
A	ARG171
A	ASP176

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q62077

Chain	Residue	Details
A	TYR506
A	TYR977

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by SYK => ECO:0000250|UniProtKB:P08487

Chain	Residue	Details
A	LYS793

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P19174

Chain	Residue	Details
A	LYS797

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by ITK, SYK and TXK => ECO:0000250|UniProtKB:P19174

Chain	Residue	Details
A	GLN805

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