7STZ

Crystal Structure of Human E-cadherin EC1-5 bound by mouse monoclonal antibody Fab mAb-1_19A11

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (C, D)	Cadherin-1	polymer	590	64179.3	2	UniProt (P12830) Pfam (PF00028)	Homo sapiens (human)	CAM 120/80,Epithelial cadherin,E-cadherin,Uvomorulin
2	B, E (H, I)	mAb-1_19A11 Heavy Chain	polymer	246	26346.9	2		Mus musculus
3	C, F (L, M)	mAb-1_19A11 Light Chain	polymer	240	26529.6	2		Mus musculus
4	AB, BB, FA, G, GA (I, H, C)	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
5	H (C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
6	CB, HA, I, IA, J (I, H, C, D)	TETRAETHYLENE GLYCOL	non-polymer		194.2	5	Chemie (PG4)
7	K, M, Q (C)	alpha-D-mannopyranose	non-polymer		180.2	3	Chemie (MAN)
8	JA, KA, L, LA, MA... (D, C)	beta-D-mannopyranose	non-polymer		180.2	12	Chemie (BMA)
9	AA, BA, CA, DA, DB... (C, M, D)	CALCIUM ION	non-polymer		40.1	24	Chemie (CA)
10	EB, FB, GB, HB, IB... (C, H, L, D, I...)	water	water		18.0	534	Chemie (HOH)

Sequence modifications

C, D: 1 - 544 (UniProt: P12830)

PDB	External Database	Details
Met -15	-	expression tag
Pro -14	-	expression tag
Leu -13	-	expression tag
Leu -12	-	expression tag
Leu -11	-	expression tag
Leu -10	-	expression tag
Leu -9	-	expression tag
Pro -8	-	expression tag
Leu -7	-	expression tag
Leu -6	-	expression tag
Trp -5	-	expression tag
Ala -4	-	expression tag
Gly -3	-	expression tag
Ala -2	-	expression tag
Leu -1	-	expression tag
Ala 0	-	expression tag

C, D: 545 - 574 (PDB: 7STZ)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	234111.5
Non-Polymers*	Number of molecules	50
	Total formula weight	5166.9
All*	Total formula weight	239278.4

*Water molecules are not included.