7STZ
Crystal Structure of Human E-cadherin EC1-5 bound by mouse monoclonal antibody Fab mAb-1_19A11
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | C, D | Cadherin-1 | polymer | 590 | 64179.3 | 2 | UniProt (P12830) Pfam (PF00028) In PDB | Homo sapiens (human) | CAM 120/80,Epithelial cadherin,E-cadherin,Uvomorulin |
2 | H, I | mAb-1_19A11 Heavy Chain | polymer | 246 | 26346.9 | 2 | Mus musculus | ||
3 | L, M | mAb-1_19A11 Light Chain | polymer | 240 | 26529.6 | 2 | Mus musculus | ||
4 | I, H, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
5 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
6 | I, H, C, D | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 5 | Chemie (PG4) | |||
7 | C | alpha-D-mannopyranose | non-polymer | 180.2 | 3 | Chemie (MAN) | |||
8 | D, C | beta-D-mannopyranose | non-polymer | 180.2 | 12 | Chemie (BMA) | |||
9 | C, M, D | CALCIUM ION | non-polymer | 40.1 | 24 | Chemie (CA) | |||
10 | water | water | 18.0 | 534 | Chemie (HOH) |
Sequence modifications
C, D: 1 - 544 (UniProt: P12830)
C, D: 545 - 574 (PDB: 7STZ)
PDB | External Database | Details |
---|---|---|
Met -15 | - | expression tag |
Pro -14 | - | expression tag |
Leu -13 | - | expression tag |
Leu -12 | - | expression tag |
Leu -11 | - | expression tag |
Leu -10 | - | expression tag |
Leu -9 | - | expression tag |
Pro -8 | - | expression tag |
Leu -7 | - | expression tag |
Leu -6 | - | expression tag |
Trp -5 | - | expression tag |
Ala -4 | - | expression tag |
Gly -3 | - | expression tag |
Ala -2 | - | expression tag |
Leu -1 | - | expression tag |
Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 234111.5 | |
Non-Polymers* | Number of molecules | 50 |
Total formula weight | 5166.9 | |
All* | Total formula weight | 239278.4 |