7STZ

Crystal Structure of Human E-cadherin EC1-5 bound by mouse monoclonal antibody Fab mAb-1_19A11

Summary for 7STZ

• Entry DOI: 10.2210/pdb7stz/pdb
• Descriptor: Cadherin-1, mAb-1_19A11 Heavy Chain, mAb-1_19A11 Light Chain, ... (10 entities in total)
• Functional Keywords: ssgcid, cadherin-1, cell adhesion, structural genomics, seattle structural genomics center for infectious disease, cell adhesion-immune system complex, cell adhesion/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 239278.42

Authors

Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2021-11-15, release date: 2022-01-26, Last modification date: 2023-10-25)

• Primary citation: Maker, A.,Bolejack, M.,Schecterson, L.,Hammerson, B.,Abendroth, J.,Edwards, T.E.,Staker, B.,Myler, P.J.,Gumbiner, B.M.; Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography.; Pnas Nexus, 1:pgac163-pgac163, 2022; PubMed: 36157596; DOI: 10.1093/pnasnexus/pgac163

Experimental method

X-RAY DIFFRACTION (2.95 Å)