7STZ

Crystal Structure of Human E-cadherin EC1-5 bound by mouse monoclonal antibody Fab mAb-1_19A11

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005509	molecular_function	calcium ion binding
C	0005886	cellular_component	plasma membrane
C	0007155	biological_process	cell adhesion
C	0007156	biological_process	homophilic cell adhesion via plasma membrane adhesion molecules
C	0016020	cellular_component	membrane
C	0098609	biological_process	cell-cell adhesion
D	0005509	molecular_function	calcium ion binding
D	0005886	cellular_component	plasma membrane
D	0007155	biological_process	cell adhesion
D	0007156	biological_process	homophilic cell adhesion via plasma membrane adhesion molecules
D	0016020	cellular_component	membrane
D	0098609	biological_process	cell-cell adhesion

Functional Information from PROSITE/UniProt

site_id	PS00232
Number of Residues	11
Details	CADHERIN_1 Cadherin domain signature. ItVtDqNDNkP

Chain	Residue	Details
C	ILE96-PRO106
C	ILE209-PRO219
C	LEU429-PRO439

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR198-HIS204

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
C	ASP103
C	ASP134
D	ASP103
D	ASP134

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by S.pyogenes SpeB => ECO:0000269|PubMed:23532847

Chain	Residue	Details
C	THR210
D	THR210

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: O-linked (Man...) serine => ECO:0000250|UniProtKB:P09803

Chain	Residue	Details
C	SER126
D	SER126

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site_id	SWS_FT_FI4
Number of Residues	16
Details	CARBOHYD: O-linked (Man...) threonine => ECO:0000250|UniProtKB:P09803

Chain	Residue	Details
C	THR131
D	THR204
D	THR316
D	THR318
D	THR355
D	THR422
D	THR424
D	THR426
C	THR204
C	THR316
C	THR318
C	THR355
C	THR422
C	THR424
C	THR426
D	THR131

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site_id	SWS_FT_FI5
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18491227

Chain	Residue	Details
C	ASN404
C	ASN416
C	ASN468
C	ASN483
D	ASN404
D	ASN416
D	ASN468
D	ASN483

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