7STZ

Crystal Structure of Human E-cadherin EC1-5 bound by mouse monoclonal antibody Fab mAb-1_19A11

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005509	molecular_function	calcium ion binding
C	0005886	cellular_component	plasma membrane
C	0007155	biological_process	cell adhesion
C	0007156	biological_process	homophilic cell-cell adhesion
C	0016020	cellular_component	membrane
C	0098609	biological_process	cell-cell adhesion
D	0005509	molecular_function	calcium ion binding
D	0005886	cellular_component	plasma membrane
D	0007155	biological_process	cell adhesion
D	0007156	biological_process	homophilic cell-cell adhesion
D	0016020	cellular_component	membrane
D	0098609	biological_process	cell-cell adhesion

Functional Information from PROSITE/UniProt

site_id	PS00232
Number of Residues	11
Details	CADHERIN_1 Cadherin domain signature. ItVtDqNDNkP

Chain	Residue	Details
C	ILE96-PRO106
C	ILE209-PRO219
C	LEU429-PRO439

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR198-HIS204

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	214
Details	Domain: {"description":"Cadherin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00043","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	224
Details	Domain: {"description":"Cadherin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00043","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	110
Details	Domain: {"description":"Cadherin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00043","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	106
Details	Domain: {"description":"Cadherin 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00043","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Cleavage; by S.pyogenes SpeB","evidences":[{"source":"PubMed","id":"23532847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (Man...) serine","evidences":[{"source":"UniProtKB","id":"P09803","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	16
Details	Glycosylation: {"description":"O-linked (Man...) threonine","evidences":[{"source":"UniProtKB","id":"P09803","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18491227","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---