7QH7
Cryo-EM structure of the human mtLSU assembly intermediate upon MRM2 depletion - class 4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (D) | 39S ribosomal protein L2, mitochondrial | polymer | 215 | 23834.5 | 1 | UniProt (Q5T653) Pfam (PF03947) Pfam (PF00181) | Homo sapiens (human) | L2mt,MRP-L2,Mitochondrial large ribosomal subunit protein uL2m |
| 2 | B (E) | 39S ribosomal protein L3, mitochondrial | polymer | 304 | 34023.1 | 1 | UniProt (P09001) Pfam (PF00297) | Homo sapiens (human) | L3mt,MRP-L3,Mitochondrial large ribosomal subunit protein uL3m |
| 3 | C (F) | 39S ribosomal protein L4, mitochondrial | polymer | 250 | 28528.1 | 1 | UniProt (Q9BYD3) Pfam (PF00573) | Homo sapiens (human) | L4mt,MRP-L4,Mitochondrial large ribosomal subunit protein uL4m |
| 4 | D (H) | 39S ribosomal protein L9, mitochondrial | polymer | 95 | 11127.0 | 1 | UniProt (Q9BYD2) Pfam (PF01281) | Homo sapiens (human) | L9mt,MRP-L9,Mitochondrial large ribosomal subunit protein bL9m |
| 5 | E (I) | 39S ribosomal protein L10, mitochondrial | polymer | 30 | 3552.3 | 1 | UniProt (Q7Z7H8) | Homo sapiens (human) | L10mt,MRP-L10,39S ribosomal protein L8,mitochondrial,L8mt,MRP-L8,Mitochondrial large ribosomal subunit protein uL10m |
| 6 | F (K) | 39S ribosomal protein L13, mitochondrial | polymer | 177 | 20591.8 | 1 | UniProt (Q9BYD1) Pfam (PF00572) | Homo sapiens (human) | L13mt,MRP-L13,Mitochondrial large ribosomal subunit protein uL13m |
| 7 | G (L) | 39S ribosomal protein L14, mitochondrial | polymer | 115 | 12710.9 | 1 | UniProt (Q6P1L8) Pfam (PF00238) | Homo sapiens (human) | L14mt,MRP-L14,39S ribosomal protein L32,mitochondrial,L32mt,MRP-L32,Mitochondrial large ribosomal subunit protein uL14m |
| 8 | H (M) | 39S ribosomal protein L15, mitochondrial | polymer | 287 | 32704.9 | 1 | UniProt (Q9P015) Pfam (PF00828) | Homo sapiens (human) | L15mt,MRP-L15,Mitochondrial large ribosomal subunit protein uL15m |
| 9 | I (N) | 39S ribosomal protein L16, mitochondrial | polymer | 201 | 23069.8 | 1 | UniProt (Q9NX20) Pfam (PF00252) | Homo sapiens (human) | L16mt,MRP-L16,Mitochondrial large ribosomal subunit protein uL16m |
| 10 | J (O) | 39S ribosomal protein L17, mitochondrial | polymer | 152 | 17761.7 | 1 | UniProt (Q9NRX2) Pfam (PF01196) | Homo sapiens (human) | L17mt,MRP-L17,LYST-interacting protein 2,Mitochondrial large ribosomal subunit protein bL17m |
| 11 | K (P) | 39S ribosomal protein L18, mitochondrial | polymer | 141 | 16335.7 | 1 | UniProt (Q9H0U6) Pfam (PF00861) | Homo sapiens (human) | L18mt,MRP-L18,Mitochondrial large ribosomal subunit protein uL18m |
| 12 | L (Q) | 39S ribosomal protein L19, mitochondrial | polymer | 217 | 25674.8 | 1 | UniProt (P49406) Pfam (PF01245) | Homo sapiens (human) | L19mt,MRP-L19,39S ribosomal protein L15,mitochondrial,L15mt,MRP-L15,Mitochondrial large ribosomal subunit protein bL19m |
| 13 | M (R) | 39S ribosomal protein L20, mitochondrial | polymer | 139 | 16251.2 | 1 | UniProt (Q9BYC9) Pfam (PF00453) | Homo sapiens (human) | L20mt,MRP-L20,Mitochondrial large ribosomal subunit protein bL20m |
| 14 | N (S) | 39S ribosomal protein L21, mitochondrial | polymer | 156 | 17794.9 | 1 | UniProt (Q7Z2W9) Pfam (PF00829) | Homo sapiens (human) | L21mt,MRP-L21,Mitochondrial large ribosomal subunit protein bL21m |
| 15 | O (T) | 39S ribosomal protein L22, mitochondrial | polymer | 166 | 19466.8 | 1 | UniProt (Q9NWU5) Pfam (PF00237) | Homo sapiens (human) | L22mt,MRP-L22,39S ribosomal protein L25,mitochondrial,L25mt,MRP-L25,Mitochondrial large ribosomal subunit protein uL22m |
| 16 | P (U) | 39S ribosomal protein L23, mitochondrial | polymer | 125 | 14562.8 | 1 | Pfam (PF00276) UniProt (by SIFTS) (Q16540) | Homo sapiens | |
| 17 | Q (V) | 39S ribosomal protein L24, mitochondrial | polymer | 48 | 5751.6 | 1 | UniProt (Q96A35) | Homo sapiens (human) | L24mt,MRP-L24,Mitochondrial large ribosomal subunit protein uL24m |
| 18 | R (W) | 39S ribosomal protein L27, mitochondrial | polymer | 100 | 11364.4 | 1 | UniProt (Q9P0M9) Pfam (PF01016) | Homo sapiens (human) | L27mt,MRP-L27,Mitochondrial large ribosomal subunit protein bL27m |
| 19 | S (X) | 39S ribosomal protein L28, mitochondrial | polymer | 243 | 28818.3 | 1 | UniProt (Q13084) Pfam (PF00830) | Homo sapiens (human) | L28mt,MRP-L28,Melanoma antigen p15,Melanoma-associated antigen recognized by T-lymphocytes,Mitochondrial large ribosomal subunit protein bL28m |
| 20 | T (Y) | 39S ribosomal protein L47, mitochondrial | polymer | 175 | 21360.9 | 1 | UniProt (Q9HD33) Pfam (PF06984) | Homo sapiens (human) | L47mt,MRP-L47,Mitochondrial large ribosomal subunit protein uL29m,Nasopharyngeal carcinoma metastasis-related protein 1 |
| 21 | U (Z) | 39S ribosomal protein L30, mitochondrial | polymer | 115 | 13332.6 | 1 | UniProt (Q8TCC3) Pfam (PF00327) | Homo sapiens (human) | L30mt,MRP-L30,39S ribosomal protein L28,mitochondrial,L28mt,MRP-L28,Mitochondrial large ribosomal subunit protein uL30m |
| 22 | V (0) | 39S ribosomal protein L32, mitochondrial | polymer | 108 | 12606.6 | 1 | UniProt (Q9BYC8) Pfam (PF01783) | Homo sapiens (human) | L32mt,MRP-L32,Mitochondrial large ribosomal subunit protein bL32m |
| 23 | W (1) | 39S ribosomal protein L33, mitochondrial | polymer | 49 | 5831.0 | 1 | UniProt (O75394) Pfam (PF00471) | Homo sapiens (human) | L33mt,MRP-L33,Mitochondrial large ribosomal subunit protein bL33m |
| 24 | X (2) | 39S ribosomal protein L34, mitochondrial | polymer | 45 | 5239.2 | 1 | UniProt (Q9BQ48) Pfam (PF00468) | Homo sapiens (human) | L34mt,MRP-L34,Mitochondrial large ribosomal subunit protein bL34m |
| 25 | Y (3) | 39S ribosomal protein L35, mitochondrial | polymer | 95 | 11788.1 | 1 | UniProt (Q9NZE8) Pfam (PF01632) | Homo sapiens (human) | L35mt,MRP-L35,Mitochondrial large ribosomal subunit protein bL35m |
| 26 | Z (5) | 39S ribosomal protein L37, mitochondrial | polymer | 392 | 45302.0 | 1 | UniProt (Q9BZE1) Pfam (PF07147) | Homo sapiens (human) | L37mt,MRP-L37,39S ribosomal protein L2,mitochondrial,L2mt,MRP-L2,Mitochondrial large ribosomal subunit protein mL37 |
| 27 | AA (6) | 39S ribosomal protein L38, mitochondrial | polymer | 292 | 34730.2 | 1 | Pfam (PF01161) UniProt (by SIFTS) (Q96DV4) | Homo sapiens | |
| 28 | BA (7) | 39S ribosomal protein L39, mitochondrial | polymer | 287 | 33289.5 | 1 | UniProt (Q9NYK5) | Homo sapiens (human) | L39mt,MRP-L39,39S ribosomal protein L5,mitochondrial,L5mt,MRP-L5,Mitochondrial large ribosomal subunit protein mL39 |
| 29 | CA (9) | 39S ribosomal protein L41, mitochondrial | polymer | 123 | 14033.0 | 1 | UniProt (Q8IXM3) Pfam (PF09809) | Homo sapiens (human) | L41mt,MRP-L41,39S ribosomal protein L27 homolog,Bcl-2-interacting mitochondrial ribosomal protein L41,Cell proliferation-inducing gene 3 protein,MRP-L27 homolog,Mitochondrial large ribosomal subunit protein mL41 |
| 30 | DA (a) | 39S ribosomal protein L42, mitochondrial | polymer | 80 | 9578.9 | 1 | Pfam (PF10210) UniProt (by SIFTS) (Q9Y6G3) | Homo sapiens | |
| 31 | EA (b) | 39S ribosomal protein L43, mitochondrial | polymer | 148 | 16742.0 | 1 | UniProt (Q8N983) Pfam (PF05047) | Homo sapiens (human) | L43mt,MRP-L43,Mitochondrial large ribosomal subunit protein mL43,Mitochondrial ribosomal protein bMRP36a |
| 32 | FA (c) | 39S ribosomal protein L44, mitochondrial | polymer | 287 | 32773.5 | 1 | UniProt (Q9H9J2) Pfam (PF22935) Pfam (PF22892) | Homo sapiens (human) | L44mt,MRP-L44,Mitochondrial large ribosomal subunit protein mL44 |
| 33 | GA (d) | 39S ribosomal protein L45, mitochondrial | polymer | 169 | 19852.9 | 1 | UniProt (Q9BRJ2) Pfam (PF04280) | Homo sapiens (human) | L45mt,MRP-L45,Mitochondrial large ribosomal subunit protein mL45 |
| 34 | HA (f) | 39S ribosomal protein L48, mitochondrial | polymer | 17 | 2019.5 | 1 | UniProt (by SIFTS) (Q96GC5) | Homo sapiens | |
| 35 | IA (g) | 39S ribosomal protein L49, mitochondrial | polymer | 129 | 15087.2 | 1 | UniProt (Q13405) Pfam (PF05046) | Homo sapiens (human) | L49mt,MRP-L49,Mitochondrial large ribosomal subunit protein mL49,Neighbor of FAU,NOF,Protein NOF1 |
| 36 | JA (h) | 39S ribosomal protein L50, mitochondrial | polymer | 105 | 12107.6 | 1 | UniProt (Q8N5N7) Pfam (PF10501) | Homo sapiens (human) | L50mt,MRP-L50,Mitochondrial large ribosomal subunit protein mL50 |
| 37 | KA (i) | 39S ribosomal protein L51, mitochondrial | polymer | 97 | 11739.9 | 1 | UniProt (Q4U2R6) Pfam (PF10244) | Homo sapiens (human) | L51mt,MRP-L51,Mitochondrial large ribosomal subunit protein mL51,bMRP-64,bMRP64 |
| 38 | LA (j) | 39S ribosomal protein L52, mitochondrial | polymer | 86 | 9802.0 | 1 | UniProt (Q86TS9) Pfam (PF18699) | Homo sapiens (human) | L52mt,MRP-L52,Mitochondrial large ribosomal subunit protein mL52 |
| 39 | MA (o) | Ribosomal protein 63, mitochondrial | polymer | 81 | 9768.3 | 1 | UniProt (Q9BQC6) Pfam (PF14978) | Homo sapiens (human) | hMRP63,Mitochondrial large ribosomal subunit protein mL63,Mitochondrial ribosomal protein 63,Mitochondrial ribosomal protein L57 |
| 40 | NA (p) | Peptidyl-tRNA hydrolase ICT1, mitochondrial | polymer | 125 | 14901.2 | 1 | Pfam (PF00472) UniProt (by SIFTS) (Q14197) | Homo sapiens | |
| 41 | OA (q) | Growth arrest and DNA damage-inducible proteins-interacting protein 1 | polymer | 101 | 11942.5 | 1 | UniProt (Q8TAE8) Pfam (PF10147) | Homo sapiens (human) | 39S ribosomal protein L59,mitochondrial,MRP-L59,CKII beta-associating protein,CR6-interacting factor 1,CRIF1,Mitochondrial large ribosomal subunit protein mL64,Papillomavirus L2-interacting nuclear protein 1,PLINP,PLINP-1,p53-responsive gene 6 protein |
| 42 | PA (r) | 39S ribosomal protein S18a, mitochondrial | polymer | 140 | 16351.2 | 1 | UniProt (Q9NVS2) Pfam (PF01084) | Homo sapiens (human) | MRP-S18-a,Mrps18a,S18mt-a,39S ribosomal protein S18-3,mitochondrial,MRP-S18-3,Mitochondrial large ribosomal subunit protein bS18a,Mitochondrial large ribosomal subunit protein mL66 |
| 43 | QA (s) | 39S ribosomal protein S30, mitochondrial | polymer | 390 | 45204.7 | 1 | UniProt (Q9NP92) Pfam (PF07147) | Homo sapiens (human) | MRP-S30,S30mt,Mitochondrial large ribosomal subunit protein mL65,Mitochondrial large ribosomal subunit protein mS30,Programmed cell death protein 9 |
| 44 | RA (u) | Mitochondrial assembly of ribosomal large subunit protein 1 | polymer | 111 | 13280.5 | 1 | UniProt (Q96EH3) Pfam (PF02410) | Homo sapiens (human) | |
| 45 | SA (v) | MIEF1 upstream open reading frame protein | polymer | 69 | 8329.6 | 1 | UniProt (L0R8F8) Pfam (PF05347) | Homo sapiens (human) | Alternative MIEF1 protein,AltMIEF1,MIEF1 microprotein,MIEF1-MP |
| 46 | TA (w) | Acyl carrier protein, mitochondrial | polymer | 79 | 9144.5 | 1 | UniProt (O14561) Pfam (PF00550) | Homo sapiens (human) | ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit |
| 47 | UA (A) | 16S ribosomal RNA | polymer | 1256 | 403061.2 | 1 | Homo sapiens | ||
| 48 | VA (B) | mitochondrial tRNAVal | polymer | 61 | 19530.7 | 1 | Homo sapiens | ||
| 49 | WA (4) | 39S ribosomal protein L36, mitochondrial | polymer | 37 | 4768.8 | 1 | UniProt (Q9P0J6) Pfam (PF00444) | Homo sapiens (human) | L36mt,MRP-L36,BRCA1-interacting protein 1,Mitochondrial large ribosomal subunit protein bL36m |
| 50 | AB, AC, BB, BC, CB... (A, E) | MAGNESIUM ION | non-polymer | 24.3 | 50 | Chemie (MG) | |||
| 51 | XC, YA, ZA (4, 0, r) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 52 | AD, BD, CD, YC, ZC (b, i, A, O, T) | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 49 |
| Total formula weight | 1247424.2 | |
| Non-Polymers* | Number of molecules | 53 |
| Total formula weight | 1411.5 | |
| All* | Total formula weight | 1248835.7 |
