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7QH7

Cryo-EM structure of the human mtLSU assembly intermediate upon MRM2 depletion - class 4

Functional Information from GO Data
ChainGOidnamespacecontents
00003735molecular_functionstructural constituent of ribosome
00006412biological_processtranslation
00015934cellular_componentlarge ribosomal subunit
10003735molecular_functionstructural constituent of ribosome
10005840cellular_componentribosome
10006412biological_processtranslation
20003735molecular_functionstructural constituent of ribosome
20005840cellular_componentribosome
20006412biological_processtranslation
30003735molecular_functionstructural constituent of ribosome
30005840cellular_componentribosome
30006412biological_processtranslation
40003735molecular_functionstructural constituent of ribosome
40005840cellular_componentribosome
40006412biological_processtranslation
50003723molecular_functionRNA binding
50003735molecular_functionstructural constituent of ribosome
50005739cellular_componentmitochondrion
50005743cellular_componentmitochondrial inner membrane
50005761cellular_componentmitochondrial ribosome
50005762cellular_componentmitochondrial large ribosomal subunit
50005840cellular_componentribosome
50006412biological_processtranslation
50032543biological_processmitochondrial translation
51990904cellular_componentribonucleoprotein complex
70000166molecular_functionnucleotide binding
90003723molecular_functionRNA binding
90003735molecular_functionstructural constituent of ribosome
90005515molecular_functionprotein binding
90005739cellular_componentmitochondrion
90005743cellular_componentmitochondrial inner membrane
90005762cellular_componentmitochondrial large ribosomal subunit
90005840cellular_componentribosome
90006412biological_processtranslation
90006915biological_processapoptotic process
90032543biological_processmitochondrial translation
91990904cellular_componentribonucleoprotein complex
b0003735molecular_functionstructural constituent of ribosome
b0032543biological_processmitochondrial translation
c0003725molecular_functiondouble-stranded RNA binding
c0004525molecular_functionribonuclease III activity
c0006396biological_processRNA processing
D0003735molecular_functionstructural constituent of ribosome
D0005840cellular_componentribosome
D0006412biological_processtranslation
E0003735molecular_functionstructural constituent of ribosome
E0005840cellular_componentribosome
E0006412biological_processtranslation
F0003735molecular_functionstructural constituent of ribosome
F0005840cellular_componentribosome
F0006412biological_processtranslation
g0003735molecular_functionstructural constituent of ribosome
g0005840cellular_componentribosome
g0006412biological_processtranslation
h0005739cellular_componentmitochondrion
H0003735molecular_functionstructural constituent of ribosome
H0005840cellular_componentribosome
H0006412biological_processtranslation
i0003735molecular_functionstructural constituent of ribosome
j0003735molecular_functionstructural constituent of ribosome
j0005762cellular_componentmitochondrial large ribosomal subunit
j0032543biological_processmitochondrial translation
K0003723molecular_functionRNA binding
K0003729molecular_functionmRNA binding
K0003735molecular_functionstructural constituent of ribosome
K0005515molecular_functionprotein binding
K0005739cellular_componentmitochondrion
K0005743cellular_componentmitochondrial inner membrane
K0005761cellular_componentmitochondrial ribosome
K0005762cellular_componentmitochondrial large ribosomal subunit
K0005840cellular_componentribosome
K0006412biological_processtranslation
K0017148biological_processnegative regulation of translation
K0032543biological_processmitochondrial translation
K1990904cellular_componentribonucleoprotein complex
L0003735molecular_functionstructural constituent of ribosome
L0005840cellular_componentribosome
L0006412biological_processtranslation
M0003723molecular_functionRNA binding
M0003735molecular_functionstructural constituent of ribosome
M0005515molecular_functionprotein binding
M0005739cellular_componentmitochondrion
M0005743cellular_componentmitochondrial inner membrane
M0005762cellular_componentmitochondrial large ribosomal subunit
M0005840cellular_componentribosome
M0006412biological_processtranslation
M0015934cellular_componentlarge ribosomal subunit
M0032543biological_processmitochondrial translation
M1990830biological_processcellular response to leukemia inhibitory factor
M1990904cellular_componentribonucleoprotein complex
N0003735molecular_functionstructural constituent of ribosome
N0005840cellular_componentribosome
N0006412biological_processtranslation
N0019843molecular_functionrRNA binding
o0005761cellular_componentmitochondrial ribosome
O0003735molecular_functionstructural constituent of ribosome
O0005840cellular_componentribosome
O0006412biological_processtranslation
P0003735molecular_functionstructural constituent of ribosome
P0005840cellular_componentribosome
P0006412biological_processtranslation
q0005634cellular_componentnucleus
Q0003735molecular_functionstructural constituent of ribosome
Q0005840cellular_componentribosome
Q0006412biological_processtranslation
r0003735molecular_functionstructural constituent of ribosome
r0005840cellular_componentribosome
r0006412biological_processtranslation
R0003723molecular_functionRNA binding
R0003735molecular_functionstructural constituent of ribosome
R0005515molecular_functionprotein binding
R0005739cellular_componentmitochondrion
R0005743cellular_componentmitochondrial inner membrane
R0005761cellular_componentmitochondrial ribosome
R0005762cellular_componentmitochondrial large ribosomal subunit
R0005840cellular_componentribosome
R0006412biological_processtranslation
R0019843molecular_functionrRNA binding
R0032543biological_processmitochondrial translation
R1990904cellular_componentribonucleoprotein complex
s0003735molecular_functionstructural constituent of ribosome
s0005739cellular_componentmitochondrion
s0005840cellular_componentribosome
s0006412biological_processtranslation
S0003723molecular_functionRNA binding
S0003735molecular_functionstructural constituent of ribosome
S0005840cellular_componentribosome
S0006412biological_processtranslation
T0003735molecular_functionstructural constituent of ribosome
T0005840cellular_componentribosome
T0006412biological_processtranslation
T0015934cellular_componentlarge ribosomal subunit
U0003735molecular_functionstructural constituent of ribosome
U0005840cellular_componentribosome
U0006412biological_processtranslation
v0000266biological_processmitochondrial fission
v0005515molecular_functionprotein binding
v0005739cellular_componentmitochondrion
v0005759cellular_componentmitochondrial matrix
v0006417biological_processregulation of translation
v0032981biological_processmitochondrial respiratory chain complex I assembly
v0042254biological_processribosome biogenesis
v0070131biological_processpositive regulation of mitochondrial translation
v0140978molecular_functionmitochondrial large ribosomal subunit binding
v1902775biological_processmitochondrial large ribosomal subunit assembly
w0006633biological_processfatty acid biosynthetic process
W0003735molecular_functionstructural constituent of ribosome
W0005840cellular_componentribosome
W0006412biological_processtranslation
X0003723molecular_functionRNA binding
X0003735molecular_functionstructural constituent of ribosome
X0005515molecular_functionprotein binding
X0005739cellular_componentmitochondrion
X0005743cellular_componentmitochondrial inner membrane
X0005761cellular_componentmitochondrial ribosome
X0005762cellular_componentmitochondrial large ribosomal subunit
X0005829cellular_componentcytosol
X0005840cellular_componentribosome
X0006412biological_processtranslation
X0032543biological_processmitochondrial translation
X1990904cellular_componentribonucleoprotein complex
Y0003735molecular_functionstructural constituent of ribosome
Y0005761cellular_componentmitochondrial ribosome
Y0006412biological_processtranslation
Z0003735molecular_functionstructural constituent of ribosome
Z0006412biological_processtranslation
Z0015934cellular_componentlarge ribosomal subunit
Functional Information from PROSITE/UniProt
site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM
ChainResidueDetails
wASP107-MET122

site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI
ChainResidueDetails
wASP132-ILE144

site_idPS00474
Number of Residues24
DetailsRIBOSOMAL_L3 Ribosomal protein L3 signature. FrpgqyvDvtAkTiGKGfqGvmkR
ChainResidueDetails
EPHE198-ARG221

site_idPS00783
Number of Residues23
DetailsRIBOSOMAL_L13 Ribosomal protein L13 signature. IYGMLPknlh.RRtmmerLhLFpD
ChainResidueDetails
KILE108-ASP130

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N5-methylglutamine => ECO:0000269|PubMed:35260756
ChainResidueDetails
pILE111
0CYS123
0CYS126

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: O-(pantetheine 4'-phosphoryl)serine => ECO:0000255|PROSITE-ProRule:PRU00258, ECO:0000269|PubMed:31664822, ECO:0007744|PDB:6ODD
ChainResidueDetails
wSER112

237992

PDB entries from 2025-06-25

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