Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7QH7

Cryo-EM structure of the human mtLSU assembly intermediate upon MRM2 depletion - class 4

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0003735	molecular_function	structural constituent of ribosome
0	0006412	biological_process	translation
0	0015934	cellular_component	large ribosomal subunit
1	0003735	molecular_function	structural constituent of ribosome
1	0005840	cellular_component	ribosome
1	0006412	biological_process	translation
2	0003735	molecular_function	structural constituent of ribosome
2	0005840	cellular_component	ribosome
2	0006412	biological_process	translation
3	0003735	molecular_function	structural constituent of ribosome
3	0005840	cellular_component	ribosome
3	0006412	biological_process	translation
4	0003735	molecular_function	structural constituent of ribosome
4	0005840	cellular_component	ribosome
4	0006412	biological_process	translation
5	0003723	molecular_function	RNA binding
5	0003735	molecular_function	structural constituent of ribosome
5	0005739	cellular_component	mitochondrion
5	0005743	cellular_component	mitochondrial inner membrane
5	0005761	cellular_component	mitochondrial ribosome
5	0005762	cellular_component	mitochondrial large ribosomal subunit
5	0005840	cellular_component	ribosome
5	0006412	biological_process	translation
5	0032543	biological_process	mitochondrial translation
5	1990904	cellular_component	ribonucleoprotein complex
7	0000166	molecular_function	nucleotide binding
9	0003723	molecular_function	RNA binding
9	0003735	molecular_function	structural constituent of ribosome
9	0005515	molecular_function	protein binding
9	0005739	cellular_component	mitochondrion
9	0005743	cellular_component	mitochondrial inner membrane
9	0005762	cellular_component	mitochondrial large ribosomal subunit
9	0005840	cellular_component	ribosome
9	0006412	biological_process	translation
9	0006915	biological_process	apoptotic process
9	0032543	biological_process	mitochondrial translation
9	1990904	cellular_component	ribonucleoprotein complex
b	0003735	molecular_function	structural constituent of ribosome
b	0032543	biological_process	mitochondrial translation
c	0003725	molecular_function	double-stranded RNA binding
c	0004525	molecular_function	ribonuclease III activity
c	0006396	biological_process	RNA processing
D	0003735	molecular_function	structural constituent of ribosome
D	0005840	cellular_component	ribosome
D	0006412	biological_process	translation
E	0003735	molecular_function	structural constituent of ribosome
E	0005840	cellular_component	ribosome
E	0006412	biological_process	translation
F	0003735	molecular_function	structural constituent of ribosome
F	0005840	cellular_component	ribosome
F	0006412	biological_process	translation
g	0003735	molecular_function	structural constituent of ribosome
g	0005840	cellular_component	ribosome
g	0006412	biological_process	translation
h	0005739	cellular_component	mitochondrion
H	0003735	molecular_function	structural constituent of ribosome
H	0005840	cellular_component	ribosome
H	0006412	biological_process	translation
i	0003735	molecular_function	structural constituent of ribosome
j	0003735	molecular_function	structural constituent of ribosome
j	0005762	cellular_component	mitochondrial large ribosomal subunit
j	0032543	biological_process	mitochondrial translation
K	0003723	molecular_function	RNA binding
K	0003729	molecular_function	mRNA binding
K	0003735	molecular_function	structural constituent of ribosome
K	0005515	molecular_function	protein binding
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005761	cellular_component	mitochondrial ribosome
K	0005762	cellular_component	mitochondrial large ribosomal subunit
K	0005840	cellular_component	ribosome
K	0006412	biological_process	translation
K	0017148	biological_process	negative regulation of translation
K	0032543	biological_process	mitochondrial translation
K	1990904	cellular_component	ribonucleoprotein complex
L	0003735	molecular_function	structural constituent of ribosome
L	0005840	cellular_component	ribosome
L	0006412	biological_process	translation
M	0003723	molecular_function	RNA binding
M	0003735	molecular_function	structural constituent of ribosome
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005762	cellular_component	mitochondrial large ribosomal subunit
M	0005840	cellular_component	ribosome
M	0006412	biological_process	translation
M	0015934	cellular_component	large ribosomal subunit
M	0032543	biological_process	mitochondrial translation
M	1990904	cellular_component	ribonucleoprotein complex
N	0003735	molecular_function	structural constituent of ribosome
N	0005840	cellular_component	ribosome
N	0006412	biological_process	translation
N	0019843	molecular_function	rRNA binding
o	0005761	cellular_component	mitochondrial ribosome
O	0003735	molecular_function	structural constituent of ribosome
O	0005840	cellular_component	ribosome
O	0006412	biological_process	translation
P	0003735	molecular_function	structural constituent of ribosome
P	0005840	cellular_component	ribosome
P	0006412	biological_process	translation
q	0005634	cellular_component	nucleus
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005840	cellular_component	ribosome
Q	0006412	biological_process	translation
r	0003735	molecular_function	structural constituent of ribosome
r	0005840	cellular_component	ribosome
r	0006412	biological_process	translation
R	0003723	molecular_function	RNA binding
R	0003735	molecular_function	structural constituent of ribosome
R	0005515	molecular_function	protein binding
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0005761	cellular_component	mitochondrial ribosome
R	0005762	cellular_component	mitochondrial large ribosomal subunit
R	0005840	cellular_component	ribosome
R	0006412	biological_process	translation
R	0019843	molecular_function	rRNA binding
R	0032543	biological_process	mitochondrial translation
R	1990904	cellular_component	ribonucleoprotein complex
s	0003735	molecular_function	structural constituent of ribosome
s	0005739	cellular_component	mitochondrion
s	0005840	cellular_component	ribosome
s	0006412	biological_process	translation
S	0003723	molecular_function	RNA binding
S	0003735	molecular_function	structural constituent of ribosome
S	0005840	cellular_component	ribosome
S	0006412	biological_process	translation
T	0003735	molecular_function	structural constituent of ribosome
T	0005840	cellular_component	ribosome
T	0006412	biological_process	translation
T	0015934	cellular_component	large ribosomal subunit
U	0003735	molecular_function	structural constituent of ribosome
U	0005840	cellular_component	ribosome
U	0006412	biological_process	translation
v	0000266	biological_process	mitochondrial fission
v	0005515	molecular_function	protein binding
v	0005739	cellular_component	mitochondrion
v	0005759	cellular_component	mitochondrial matrix
v	0006417	biological_process	regulation of translation
v	0032981	biological_process	mitochondrial respiratory chain complex I assembly
v	0042254	biological_process	ribosome biogenesis
v	0070131	biological_process	positive regulation of mitochondrial translation
v	0140978	molecular_function	mitochondrial large ribosomal subunit binding
v	1902775	biological_process	mitochondrial large ribosomal subunit assembly
w	0006633	biological_process	fatty acid biosynthetic process
W	0003735	molecular_function	structural constituent of ribosome
W	0005840	cellular_component	ribosome
W	0006412	biological_process	translation
X	0003723	molecular_function	RNA binding
X	0003735	molecular_function	structural constituent of ribosome
X	0005515	molecular_function	protein binding
X	0005739	cellular_component	mitochondrion
X	0005743	cellular_component	mitochondrial inner membrane
X	0005761	cellular_component	mitochondrial ribosome
X	0005762	cellular_component	mitochondrial large ribosomal subunit
X	0005840	cellular_component	ribosome
X	0006412	biological_process	translation
X	0032543	biological_process	mitochondrial translation
X	1990904	cellular_component	ribonucleoprotein complex
Y	0003735	molecular_function	structural constituent of ribosome
Y	0005761	cellular_component	mitochondrial ribosome
Y	0006412	biological_process	translation
Z	0003735	molecular_function	structural constituent of ribosome
Z	0006412	biological_process	translation
Z	0015934	cellular_component	large ribosomal subunit

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
w	ASP107-MET122

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
w	ASP132-ILE144

site_id	PS00474
Number of Residues	24
Details	RIBOSOMAL_L3 Ribosomal protein L3 signature. FrpgqyvDvtAkTiGKGfqGvmkR

Chain	Residue	Details
E	PHE198-ARG221

site_id	PS00783
Number of Residues	23
Details	RIBOSOMAL_L13 Ribosomal protein L13 signature. IYGMLPknlh.RRtmmerLhLFpD

Chain	Residue	Details
K	ILE108-ASP130

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	97
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	27
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	12
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28892042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QH7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28892042","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	66
Details	Domain: {"description":"TGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU01228","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	70
Details	Domain: {"description":"DRBM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00266","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Motif: {"description":"LYR motif","evidences":[{"source":"PubMed","id":"29083303","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30215512","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	75
Details	Domain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9CR21","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31664822","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ODD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)