7PL1
Crystal structure of human METTL1 bound to Sinefungin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | tRNA (guanine-N(7)-)-methyltransferase | polymer | 252 | 29178.3 | 1 | UniProt (Q9UBP6) Pfam (PF02390) In PDB | Homo sapiens (human) | Methyltransferase-like protein 1,mRNA (guanine-N(7)-)-methyltransferase,miRNA (guanine-N(7)-)-methyltransferase,tRNA (guanine(46)-N(7))-methyltransferase,tRNA(m7G46)-methyltransferase |
2 | A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
3 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
4 | A | SINEFUNGIN | non-polymer | 381.4 | 1 | Chemie (SFG) | |||
5 | water | water | 18.0 | 184 | Chemie (HOH) |
Sequence modifications
A: 2 - 235 (UniProt: Q9UBP6)
PDB | External Database | Details |
---|---|---|
Met -16 | - | initiating methionine |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Arg -6 | - | expression tag |
Glu -5 | - | expression tag |
Asn -4 | - | expression tag |
Leu -3 | - | expression tag |
Tyr -2 | - | expression tag |
Phe -1 | - | expression tag |
Gln 0 | - | expression tag |
Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 29178.3 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 976.0 | |
All* | Total formula weight | 30154.4 |