7PL1

Crystal structure of human METTL1 bound to Sinefungin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	tRNA (guanine-N(7)-)-methyltransferase	polymer	252	29178.3	1	UniProt (Q9UBP6) Pfam (PF02390)	Homo sapiens (human)	Methyltransferase-like protein 1,mRNA (guanine-N(7)-)-methyltransferase,miRNA (guanine-N(7)-)-methyltransferase,tRNA (guanine(46)-N(7))-methyltransferase,tRNA(m7G46)-methyltransferase
2	B, C, G (A)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
3	D, E, F (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	3	Chemie (PEG)
4	H (A)	SINEFUNGIN	non-polymer		381.4	1	Chemie (SFG)
5	I (A)	water	water		18.0	184	Chemie (HOH)

Sequence modifications

A: 2 - 235 (UniProt: Q9UBP6)

PDB	External Database	Details
Met -16	-	initiating methionine
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Arg -6	-	expression tag
Glu -5	-	expression tag
Asn -4	-	expression tag
Leu -3	-	expression tag
Tyr -2	-	expression tag
Phe -1	-	expression tag
Gln 0	-	expression tag
Gly 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	29178.3
Non-Polymers*	Number of molecules	7
	Total formula weight	976.0
All*	Total formula weight	30154.4

*Water molecules are not included.