7PL1
Crystal structure of human METTL1 bound to Sinefungin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | tRNA (guanine-N(7)-)-methyltransferase | polymer | 252 | 29178.3 | 1 | UniProt (Q9UBP6) Pfam (PF02390) | Homo sapiens (human) | Methyltransferase-like protein 1,mRNA (guanine-N(7)-)-methyltransferase,miRNA (guanine-N(7)-)-methyltransferase,tRNA (guanine(46)-N(7))-methyltransferase,tRNA(m7G46)-methyltransferase |
| 2 | B, C, G (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) PubChem (753) | |||
| 3 | D, E, F (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) PubChem (8117) | |||
| 4 | H (A) | SINEFUNGIN | non-polymer | 381.4 | 1 | Chemie (SFG) PubChem (176612030) PubChem (177116271) PubChem (25246236) PubChem (46875078) PubChem (46936257) PubChem (70602121) PubChem (456189) PubChem (4065234) PubChem (65482) PubChem (70789212) PubChem (93287274) PubChem (92403972) PubChem (93287270) PubChem (93287272) PubChem (93475589) PubChem (6917665) PubChem (12771338) PubChem (12771337) PubChem (131971033) PubChem (131972810) PubChem (138626357) PubChem (156562738) PubChem (162866891) PubChem (163339130) PubChem (168280605) | |||
| 5 | I (A) | water | water | 18.0 | 184 | Chemie (HOH) |
Sequence modifications
A: 2 - 235 (UniProt: Q9UBP6)
| PDB | External Database | Details |
|---|---|---|
| Met -16 | - | initiating methionine |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Arg -6 | - | expression tag |
| Glu -5 | - | expression tag |
| Asn -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Tyr -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Gln 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29178.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 976.0 | |
| All* | Total formula weight | 30154.4 |
