7PL1

Crystal structure of human METTL1 bound to Sinefungin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006400	biological_process	tRNA modification
A	0008176	molecular_function	tRNA (guanine(46)-N7)-methyltransferase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:36599982, ECO:0000305|PubMed:36599985

Chain	Residue	Details
A	ASP133

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:36599982, ECO:0000269|Ref.19, ECO:0007744|PDB:3CKK, ECO:0007744|PDB:8D9L

Chain	Residue	Details
A	ASN110
A	THR208
A	GLY54
A	GLU77

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:36599985, ECO:0007744|PDB:8CTH

Chain	Residue	Details
A	ILE78

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|Ref.19, ECO:0007744|PDB:3CKK

Chain	Residue	Details
A	ARG79
A	ALA111
A	LEU130
A	GLU210

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