7MYZ

Structure of the full length 5-TM receptor CD47 bound to Fab B6H12

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (C, D)	Fusion protein of Leukocyte surface antigen CD47 an Soluble cytochrome b562	polymer	421	46644.9	2	UniProt (Q08722) UniProt (P0ABE7) Pfam (PF08204) Pfam (PF04549) Pfam (PF07361)	Homo sapiens (Human)	Antigenic surface determinant protein OA3,Integrin-associated protein,IAP,Protein MER6,Cytochrome b-562,Antigenic surface determinant protein OA3,Integrin-associated protein,IAP,Protein MER6
2	C, D (H, I)	B6H12 Fab heavy chain	polymer	220	23264.1	2		Homo sapiens (Human)
3	E, F (L, M)	B6H12 Fab light chain	polymer	213	23270.8	2		Homo sapiens (Human)
4	G, H, I, J, K... (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	7	Chemie (NAG)
5	N (L)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	O, P (I, L)	water	water		18.0	3	Chemie (HOH)

Sequence modifications

C, D: 1 - 147 (UniProt: Q08722)
C, D: 147 - 151 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 147	Met 29	conflict
Ile 151	His 124	conflict
Leu 151	-	linker

C, D: 151 - 305 (UniProt: Q08722)

PDB	External Database	Details
His 306	-	expression tag
His 307	-	expression tag
His 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag
His 313	-	expression tag
His 314	-	expression tag
His 315	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	186359.5
Non-Polymers*	Number of molecules	8
	Total formula weight	1640.5
All*	Total formula weight	188000.1

*Water molecules are not included.