7MYZ
Structure of the full length 5-TM receptor CD47 bound to Fab B6H12
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0020037 | molecular_function | heme binding |
| C | 0022409 | biological_process | positive regulation of cell-cell adhesion |
| C | 0022900 | biological_process | electron transport chain |
| C | 0042597 | cellular_component | periplasmic space |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0050729 | biological_process | positive regulation of inflammatory response |
| C | 0050766 | biological_process | positive regulation of phagocytosis |
| C | 0070053 | molecular_function | thrombospondin receptor activity |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0009055 | molecular_function | electron transfer activity |
| D | 0020037 | molecular_function | heme binding |
| D | 0022409 | biological_process | positive regulation of cell-cell adhesion |
| D | 0022900 | biological_process | electron transport chain |
| D | 0042597 | cellular_component | periplasmic space |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0050729 | biological_process | positive regulation of inflammatory response |
| D | 0050766 | biological_process | positive regulation of phagocytosis |
| D | 0070053 | molecular_function | thrombospondin receptor activity |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR192-HIS198 | |
| H | TYR199-HIS205 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 284 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| C | GLN1-GLU123 | |
| C | VAL180-ALA189 | |
| C | SER239-GLY250 | |
| D | GLN1-GLU123 | |
| D | VAL286-ALA295 | |
| D | SER345-GLY356 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 200 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| C | ASN124-ILE144 | |
| D | PRO357-MET377 | |
| C | ILE159-PHE179 | |
| C | THR190-PHE210 | |
| C | SER218-LEU238 | |
| C | PRO251-MET271 | |
| D | ASN124-ILE144 | |
| D | ILE265-PHE285 | |
| D | THR296-PHE316 | |
| D | SER324-LEU344 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 78 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| C | SER211-THR217 | |
| C | LYS272-GLU305 | |
| D | SER317-THR323 | |
| D | LYS378-GLU411 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:18657508 |
| Chain | Residue | Details |
| C | GLN1 | |
| D | GLN1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97829 |
| Chain | Residue | Details |
| C | SER71 | |
| D | SER71 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18657508 |
| Chain | Residue | Details |
| C | ASN5 | |
| D | ASN5 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine |
| Chain | Residue | Details |
| C | ASN16 | |
| D | ASN16 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18657508, ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| C | ASN32 | |
| D | ASN32 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18657508, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| C | ASN55 | |
| D | ASN55 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18657508, ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| C | ASN93 | |
| D | ASN93 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| C | ASN188 | |
| D | ASN294 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| C | TRP147 | |
| C | ILE151 | |
| D | TRP159 | |
| D | ILE254 |
