7KX0
Crystal structure of the CD27:CD70 co-stimulatory complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | CD70 antigen | polymer | 158 | 17482.7 | 3 | UniProt (P32970) Pfam (PF00229) | Homo sapiens (Human) | CD27 ligand,CD27-L,Tumor necrosis factor ligand superfamily member 7 |
| 2 | D, E, F (D, E, F) | CD27 antigen | polymer | 114 | 12782.4 | 3 | UniProt (P26842) Pfam (PF00020) | Homo sapiens (Human) | CD27L receptor,T-cell activation antigen CD27,T14,Tumor necrosis factor receptor superfamily member 7 |
| 3 | G, I (G, I) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 2 | In PDB GlyTouCan (G32152BH) | |||
| 4 | H (H) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 5 | J, L (J, L) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 6 | K (K) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 1 | In PDB GlyTouCan (G00395TQ) | |||
| 7 | M (C) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 8 | N, O, P (D, E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 9 | Q, R, S, T, U... (A, B, C, D, E...) | water | water | 18.0 | 145 | Chemie (HOH) |
Sequence modifications
A, B, C: 45 - 193 (UniProt: P32970)
D, E, F: 23 - 127 (UniProt: P26842)
| PDB | External Database | Details |
|---|---|---|
| His 36 | - | expression tag |
| His 37 | - | expression tag |
| His 38 | - | expression tag |
| His 39 | - | expression tag |
| His 40 | - | expression tag |
| His 41 | - | expression tag |
| Gly 42 | - | expression tag |
| Ser 43 | - | expression tag |
| Gly 44 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 128 | - | expression tag |
| Ser 129 | - | expression tag |
| Gly 130 | - | expression tag |
| His 131 | - | expression tag |
| His 132 | - | expression tag |
| His 133 | - | expression tag |
| His 134 | - | expression tag |
| His 135 | - | expression tag |
| His 136 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 90795.5 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 4930.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 785.8 | |
| All* | Total formula weight | 96511.8 |
