7KX0
Crystal structure of the CD27:CD70 co-stimulatory complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005164 | molecular_function | tumor necrosis factor receptor binding |
| A | 0006955 | biological_process | immune response |
| A | 0016020 | cellular_component | membrane |
| A | 0033209 | biological_process | tumor necrosis factor-mediated signaling pathway |
| B | 0005164 | molecular_function | tumor necrosis factor receptor binding |
| B | 0006955 | biological_process | immune response |
| B | 0016020 | cellular_component | membrane |
| B | 0033209 | biological_process | tumor necrosis factor-mediated signaling pathway |
| C | 0005164 | molecular_function | tumor necrosis factor receptor binding |
| C | 0006955 | biological_process | immune response |
| C | 0016020 | cellular_component | membrane |
| C | 0033209 | biological_process | tumor necrosis factor-mediated signaling pathway |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0006915 | biological_process | apoptotic process |
| D | 0006955 | biological_process | immune response |
| D | 0007165 | biological_process | signal transduction |
| D | 0016020 | cellular_component | membrane |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0006915 | biological_process | apoptotic process |
| E | 0006955 | biological_process | immune response |
| E | 0007165 | biological_process | signal transduction |
| E | 0016020 | cellular_component | membrane |
| F | 0004888 | molecular_function | transmembrane signaling receptor activity |
| F | 0006915 | biological_process | apoptotic process |
| F | 0006955 | biological_process | immune response |
| F | 0007165 | biological_process | signal transduction |
| F | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00251 |
| Number of Residues | 17 |
| Details | THD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LrIHrDGIYMVhiQVtL |
| Chain | Residue | Details |
| A | LEU96-LEU112 |
| site_id | PS00652 |
| Number of Residues | 42 |
| Details | TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. Cipgvs.Fspdhhtrph.CesCrh.Cnsgllvrn...CtitanaECAC |
| Chain | Residue | Details |
| D | CYS65-CYS106 |
| site_id | PS01186 |
| Number of Residues | 14 |
| Details | EGF_2 EGF-like domain signature 2. CaCrnGWqcrdke..C |
| Chain | Residue | Details |
| D | CYS104-CYS117 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 405 |
| Details | Domain: {"description":"THD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01387","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 111 |
| Details | Repeat: {"description":"TNFR-Cys 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 120 |
| Details | Repeat: {"description":"TNFR-Cys 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"34419446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7KX0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
