7E2I
Cryo-EM structure of hDisp1NNN-ShhN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (G) | Sonic hedgehog protein | polymer | 462 | 49676.2 | 1 | UniProt (Q15465) Pfam (PF01085) Pfam (PF01079) | Homo sapiens (Human) | SHH,HHG-1,Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains,ShhNC |
| 2 | B (D) | Protein dispatched homolog 1 | polymer | 1524 | 171110.1 | 1 | UniProt (Q96F81) Pfam (PF12349) Pfam (PF03176) | Homo sapiens (Human) | |
| 3 | C (G) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, E, F, G, H... (D) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 7 | Chemie (Y01) | |||
| 5 | K, L, M, N (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
D: 1 - 1524 (UniProt: Q96F81)
| PDB | External Database | Details |
|---|---|---|
| Asn 572 | Asp 572 | engineered mutation |
| Asn 573 | Asp 573 | engineered mutation |
| Asn 1051 | Asp 1051 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 220786.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4357.3 | |
| All* | Total formula weight | 225143.6 |
