7E2I
Cryo-EM structure of hDisp1NNN-ShhN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| D | 0005515 | molecular_function | protein binding |
| D | 0007224 | biological_process | smoothened signaling pathway |
| D | 0015833 | biological_process | peptide transport |
| D | 0016020 | cellular_component | membrane |
| D | 0016323 | cellular_component | basolateral plasma membrane |
| D | 0050708 | biological_process | regulation of protein secretion |
| D | 0060539 | biological_process | diaphragm development |
| G | 0007267 | biological_process | cell-cell signaling |
| G | 0007275 | biological_process | multicellular organism development |
| G | 0016539 | biological_process | intein-mediated protein splicing |
| G | 0016540 | biological_process | protein autoprocessing |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29954986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31127104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29954986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30139912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31127104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30139912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10753901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29954986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30139912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31127104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31555730","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3M1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RMG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 240 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 172 |
| Details | Domain: {"description":"SSD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00199","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
