7E2I
Cryo-EM structure of hDisp1NNN-ShhN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| D | 0005515 | molecular_function | protein binding |
| D | 0007224 | biological_process | smoothened signaling pathway |
| D | 0007225 | biological_process | patched ligand maturation |
| D | 0007368 | biological_process | determination of left/right symmetry |
| D | 0009880 | biological_process | embryonic pattern specification |
| D | 0009953 | biological_process | dorsal/ventral pattern formation |
| D | 0015833 | biological_process | peptide transport |
| D | 0016020 | cellular_component | membrane |
| D | 0016323 | cellular_component | basolateral plasma membrane |
| D | 0050708 | biological_process | regulation of protein secretion |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0060539 | biological_process | diaphragm development |
| D | 0070207 | biological_process | protein homotrimerization |
| D | 1904680 | molecular_function | peptide transmembrane transporter activity |
| G | 0007267 | biological_process | cell-cell signaling |
| G | 0007275 | biological_process | multicellular organism development |
| G | 0016539 | biological_process | intein-mediated protein splicing |
| G | 0016540 | biological_process | protein autoprocessing |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 240 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| D | VAL190-VAL210 | |
| D | LEU500-VAL520 | |
| D | MET525-LEU545 | |
| D | VAL549-ILE569 | |
| D | ALA604-VAL624 | |
| D | GLY638-LEU658 | |
| D | TYR719-ASN739 | |
| D | MET988-ILE1008 | |
| D | LEU1010-LEU1030 | |
| D | VAL1040-TYR1060 | |
| D | VAL1079-PRO1099 | |
| D | GLN1107-PHE1127 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| D | ASN59 | |
| D | ASN582 | |
| G | HIS182 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:Q02936 |
| Chain | Residue | Details |
| G | GLY197 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Involved in cholesterol transfer => ECO:0000250|UniProtKB:Q02936 |
| Chain | Residue | Details |
| G | ASP243 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: Involved in auto-cleavage => ECO:0000250|UniProtKB:Q02936 |
| Chain | Residue | Details |
| G | THR267 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Essential for auto-cleavage => ECO:0000250|UniProtKB:Q02936 |
| Chain | Residue | Details |
| G | HIS270 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | LIPID: N-palmitoyl cysteine => ECO:0000269|PubMed:18534984, ECO:0000269|PubMed:31875564, ECO:0000269|PubMed:9593755 |
| Chain | Residue | Details |
| G | CYS24 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | LIPID: Cholesterol glycine ester => ECO:0000250|UniProtKB:Q62226 |
| Chain | Residue | Details |
| G | GLY197 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| G | ASN278 |
