7E1X
Cryo-EM structure of hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV in presence of TB47
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | E, Q | Cytochrome c oxidase subunit 2 | polymer | 341 | 38077.5 | 2 | UniProt (A0R057) Pfam (PF00116) In PDB | Mycobacterium smegmatis MC2 51 | Cytochrome C oxidase subunit II ctaC |
2 | F, R | Cytochrome c oxidase subunit 1 | polymer | 575 | 64163.0 | 2 | Mycolicibacterium smegmatis MC2 51 | ||
3 | G, S | Cytochrome c oxidase subunit 3 | polymer | 203 | 22196.9 | 2 | UniProt (A0R049) Pfam (PF00510) In PDB | Mycobacterium smegmatis MC2 51 | Cytochrome c oxidase subunit 3 CtaE |
4 | H, T | Cytochrome c oxidase polypeptide 4 | polymer | 139 | 15177.4 | 2 | UniProt (A0R056) Pfam (PF12270) In PDB | Mycobacterium smegmatis MC2 51 | Cytochrome aa3 subunit 4,Cytochrome c oxidase polypeptide IV |
5 | I, U | Cytochrome c oxidase subunit CtaJ | polymer | 79 | 8365.5 | 2 | UniProt (A0R1B6) In PDB | Mycobacterium smegmatis MC2 51 | |
6 | J, V | Uncharacterized protein MSMEG_4692/MSMEI_4575 | polymer | 157 | 15911.0 | 2 | UniProt (A0R1B5) Pfam (PF17174) In PDB | Mycobacterium smegmatis MC2 51 | Cytochrome c oxidase subunit CtaI |
7 | D, P | Prokaryotic respiratory supercomplex associate factor 1 PRSAF1 | polymer | 100 | 11329.9 | 2 | Mycolicibacterium smegmatis MC2 51 | ||
8 | N, B | Cytochrome bc1 complex cytochrome b subunit | polymer | 549 | 61077.1 | 2 | UniProt (P9WP37) Pfam (PF13631) In PDB | Mycobacterium tuberculosis H37Rv | Cytochrome bc1 reductase complex subunit QcrB,Ubiquinol--cytochrome c reductase cytochrome b subunit |
9 | M, A | Cytochrome bc1 complex Rieske iron-sulfur subunit | polymer | 429 | 46976.5 | 2 | UniProt (P9WH23) Pfam (PF19297) Pfam (PF00355) In PDB | Mycobacterium tuberculosis H37Rv | Cytochrome bc1 reductase complex subunit QcrA,Rieske iron-sulfur protein,Ubiquinol--cytochrome c reductase iron-sulfur subunit |
10 | O, C | Cytochrome bc1 complex cytochrome c subunit | polymer | 280 | 29152.4 | 2 | UniProt (P9WP35) Pfam (PF00034) Pfam (PF13442) In PDB | Mycobacterium tuberculosis H37Rv | Cytochrome bc1 reductase complex subunit QcrC,Ubiquinol--cytochrome c reductase cytochrome c subunit |
11 | F, Q, R, E | COPPER (II) ION | non-polymer | 63.5 | 8 | Chemie (CU) | |||
12 | M, O, D, R, B... | CARDIOLIPIN | non-polymer | 1464.0 | 17 | Chemie (CDL) | |||
13 | R, B, N, F | PALMITIC ACID | non-polymer | 256.4 | 4 | Chemie (PLM) | |||
14 | F, R | HEME-A | non-polymer | 852.8 | 4 | Chemie (HEA) | |||
15 | G, S | (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate | non-polymer | 718.0 | 2 | Chemie (9Y0) | |||
16 | B, N | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
17 | C, O, B, A, N | MENAQUINONE-9 | non-polymer | 785.2 | 8 | Chemie (MQ9) | |||
18 | B, N | 5-methoxy-2-methyl-~{N}-[[4-[4-[4-(trifluoromethyloxy)phenyl]piperidin-1-yl]phenyl]methyl]pyrazolo[1,5-a]pyridine-3-carboxamide | non-polymer | 538.6 | 2 | Chemie (HV0) | |||
19 | A, M | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
20 | M, A | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate | non-polymer | 853.1 | 4 | Chemie (9YF) | |||
21 | O, C | HEME C | non-polymer | 618.5 | 4 | Chemie (HEC) |
Sequence modifications
O, C: 2 - 280 (UniProt: P9WP35)
PDB | External Database | Details |
---|---|---|
Leu 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 20 |
Total formula weight | 624854.1 | |
Non-Polymers* | Number of molecules | 59 |
Total formula weight | 47333.2 | |
All* | Total formula weight | 672187.3 |