Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7E1X

Cryo-EM structure of hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV in presence of TB47

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
A	0070469	cellular_component	respirasome
B	0005886	cellular_component	plasma membrane
B	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
B	0009055	molecular_function	electron transfer activity
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0022904	biological_process	respiratory electron transport chain
B	0046872	molecular_function	metal ion binding
B	0070469	cellular_component	respirasome
B	1902600	biological_process	proton transmembrane transport
C	0005506	molecular_function	iron ion binding
C	0005886	cellular_component	plasma membrane
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0020037	molecular_function	heme binding
C	0046872	molecular_function	metal ion binding
C	0070469	cellular_component	respirasome
C	1902600	biological_process	proton transmembrane transport
E	0004129	molecular_function	cytochrome-c oxidase activity
E	0005507	molecular_function	copper ion binding
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0042773	biological_process	ATP synthesis coupled electron transport
E	0046872	molecular_function	metal ion binding
E	1902600	biological_process	proton transmembrane transport
F	0004129	molecular_function	cytochrome-c oxidase activity
F	0009060	biological_process	aerobic respiration
F	0015990	biological_process	electron transport coupled proton transport
F	0016020	cellular_component	membrane
F	0020037	molecular_function	heme binding
G	0004129	molecular_function	cytochrome-c oxidase activity
G	0005886	cellular_component	plasma membrane
G	0009055	molecular_function	electron transfer activity
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0019646	biological_process	aerobic electron transport chain
G	0022904	biological_process	respiratory electron transport chain
G	1902600	biological_process	proton transmembrane transport
H	0004129	molecular_function	cytochrome-c oxidase activity
H	0005886	cellular_component	plasma membrane
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0022900	biological_process	electron transport chain
H	1902600	biological_process	proton transmembrane transport
I	0016020	cellular_component	membrane
M	0005886	cellular_component	plasma membrane
M	0009274	cellular_component	peptidoglycan-based cell wall
M	0016491	molecular_function	oxidoreductase activity
M	0046872	molecular_function	metal ion binding
M	0051537	molecular_function	2 iron, 2 sulfur cluster binding
M	0070469	cellular_component	respirasome
N	0005886	cellular_component	plasma membrane
N	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
N	0009055	molecular_function	electron transfer activity
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0022904	biological_process	respiratory electron transport chain
N	0046872	molecular_function	metal ion binding
N	0070469	cellular_component	respirasome
N	1902600	biological_process	proton transmembrane transport
O	0005506	molecular_function	iron ion binding
O	0005886	cellular_component	plasma membrane
O	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
O	0009055	molecular_function	electron transfer activity
O	0016020	cellular_component	membrane
O	0020037	molecular_function	heme binding
O	0046872	molecular_function	metal ion binding
O	0070469	cellular_component	respirasome
O	1902600	biological_process	proton transmembrane transport
Q	0004129	molecular_function	cytochrome-c oxidase activity
Q	0005507	molecular_function	copper ion binding
Q	0016020	cellular_component	membrane
Q	0016491	molecular_function	oxidoreductase activity
Q	0042773	biological_process	ATP synthesis coupled electron transport
Q	0046872	molecular_function	metal ion binding
Q	1902600	biological_process	proton transmembrane transport
R	0004129	molecular_function	cytochrome-c oxidase activity
R	0009060	biological_process	aerobic respiration
R	0015990	biological_process	electron transport coupled proton transport
R	0016020	cellular_component	membrane
R	0020037	molecular_function	heme binding
S	0004129	molecular_function	cytochrome-c oxidase activity
S	0005886	cellular_component	plasma membrane
S	0009055	molecular_function	electron transfer activity
S	0016020	cellular_component	membrane
S	0016491	molecular_function	oxidoreductase activity
S	0019646	biological_process	aerobic electron transport chain
S	0022904	biological_process	respiratory electron transport chain
S	1902600	biological_process	proton transmembrane transport
T	0004129	molecular_function	cytochrome-c oxidase activity
T	0005886	cellular_component	plasma membrane
T	0016020	cellular_component	membrane
T	0016491	molecular_function	oxidoreductase activity
T	0022900	biological_process	electron transport chain
T	1902600	biological_process	proton transmembrane transport
U	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiialpffgivseifpvfsrkpifgyttliyatlaiaalsvavwa..HH

Chain	Residue	Details
F	TRP260-HIS314

site_id	PS00078
Number of Residues	55
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHgfwvpeflfkrdvlpepkannsdnvfqvseiqqtgafvgrCtemCgtfHamM

Chain	Residue	Details
E	VAL230-MET284

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
M	VAL96-PHE116
M	PRO137-TYR157
M	PHE207-ILE227
A	VAL96-PHE116
A	PRO137-TYR157
A	PHE207-ILE227
N	PRO335-LEU355
N	ILE381-ILE401
N	ILE418-LEU438
B	PHE45-LEU65
B	ALA118-PHE138
B	TRP146-LEU166
B	VAL189-ILE209
B	ILE217-PHE237
B	SER266-ILE286
B	PRO335-LEU355
B	ILE381-ILE401
B	ILE418-LEU438

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00628

Chain	Residue	Details
M	CYS353
A	CYS353
A	HIS355
A	CYS372
A	HIS375
M	HIS355
M	CYS372
M	HIS375

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000255\|PROSITE-ProRule:PRU00433

Chain	Residue	Details
O	HIS77
O	HIS178
C	HIS77
C	HIS178

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)