7E14
Compound2_GLP-1R_OWL833_Gs complex structure
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Gs | polymer | 246 | 28989.9 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63092) | Homo sapiens | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62871) Pfam (PF00400) UniProt (by SIFTS) (P62873) | Bos taurus (Bovine) | Transducin beta chain 1 |
| 3 | C (G) | G protein | polymer | 71 | 7861.1 | 1 | Pfam (PF00631) UniProt (by SIFTS) (P59768) | Rattus norvegicus | |
| 4 | D (N) | Nb35 | polymer | 128 | 13885.4 | 1 | synthetic construct | ||
| 5 | E (R) | Glucagon-like peptide 1 receptor | polymer | 440 | 50860.8 | 1 | UniProt (P43220) Pfam (PF02793) Pfam (PF00002) | Homo sapiens (Human) | GLP-1R |
| 6 | F (R) | 3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one | non-polymer | 883.0 | 1 | Chemie (V6G) | |||
| 7 | G, H, I, J, K (R) | CHOLESTEROL | non-polymer | 386.7 | 5 | Chemie (CLR) | |||
| 8 | L (R) | N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine | non-polymer | 270.2 | 1 | Chemie (HNO) |
Sequence modifications
B: 2 - 340 (UniProt: P62871)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 139512.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 3086.4 | |
| All* | Total formula weight | 142599.2 |
